Evidence map›Paper›PMID 31610692›Full record

ArticleCirculation. Arrhythmia and electrophysiology2019

Atrial Fibrillation in Long QT Syndrome by Genotype.

Pyotr G Platonov, Scott McNitt, Bronislava Polonsky, Spencer Z Rosero, Wojciech Zareba

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Activation of Small Conductance CaInternational journal of molecular sciences · 2025
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. COVID-19 HEART unveiling as atrial fibrillation: pathophysiology, management and future directions for research.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2023
    Review
  19. Review
  20. Effects of Pulsed Radiofrequency Source on Cardiac Ablation.Bioengineering (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Pyotr G PlatonovDepartment of Cardiology, Clinical Sciences, Lund University, Sweden (P.G.P.).
Scott McNittClinical Cardiovascular Research Center, Division of Cardiology, University of Rochester Medical Center, NY (P.G.P., S.M., B.P., S.Z.R., W.Z.).
Bronislava PolonskyClinical Cardiovascular Research Center, Division of Cardiology, University of Rochester Medical Center, NY (P.G.P., S.M., B.P., S.Z.R., W.Z.).
Spencer Z RoseroClinical Cardiovascular Research Center, Division of Cardiology, University of Rochester Medical Center, NY (P.G.P., S.M., B.P., S.Z.R., W.Z.).
Wojciech ZarebaClinical Cardiovascular Research Center, Division of Cardiology, University of Rochester Medical Center, NY (P.G.P., S.M., B.P., S.Z.R., W.Z.).
University of Rochester Medical Center · USLund University · SE

Funding

Clinical and Basic Science Studies in Long QT Syndrome Type 3R01HL123483 · NHLBI · UNIVERSITY OF ROCHESTER · PI KASS, ROBERT S, ZAREBA, WOJCIECH · 2014 to 2018
$3.7M
NHLBI NIH HHS R01 HL123483
6 · The paper itself

Abstract

backgroundLong QT syndrome (LQTS) is caused by the abnormal function of ion channels, which may also affect atrial electrophysiology and be associated with the risk of atrial fibrillation (AF). However, large-scale studies of AF risk among patients with LQTS and its relation to LQTS manifestations are lacking. We aimed to assess the risk of AF and its relationship to the LQTS genotype and the long-term prognosis in patients with LQTS.

methodsGenotype-positive patients with LQTS (784 LQT1, 746 LQT2, and 233 LQT3) were compared with 2043 genotype-negative family members. Information on the occurrence of AF was based on physician-reported ECG-verified events. Multivariate Cox proportional hazards regression analyses were performed for ages 0 to 60 and after 60 years (reflecting an early and late-onset of AF) to assess the risk of incident AF by genotype and the relationship of AF to the risk of cardiac events defined as syncope, documented torsades de pointes, and aborted cardiac arrest or sudden cardiac death.

resultsIn patients followed from birth to 60 years of age, patients with LQT3 had an increased risk of AF compared with genotype-negative family members (hazard ratio=6.62; 95% CI, 2.04-21.49;

conclusionsOur data demonstrate an increased risk of early age AF in patients with LQT3 and also indicate a protective effect of the LQT2 genotype in it's association with a decreased risk of AF after the age of 60.

Indexed as

ElectrocardiographyAdolescentAdultAgedAtrial FibrillationChildChild, PreschoolDNADNA Mutational AnalysisERG1 Potassium ChannelFollow-Up StudiesGenotypeHumansInfantInfant, NewbornKCNQ1 Potassium ChannelDNAERG1 Potassium ChannelKCNH2 protein, humanKCNQ1 Potassium ChannelNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humanatrial fibrillationelectrophysiologygenotypelong QT syndromesudden cardiac death

Identifiers

PMID31610692
PMCPMC6814383
OpenAlexW2981170480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.