ArticleCirculation. Cardiovascular imaging2019
Myocardial Fibrosis and Prognosis in Heart Transplant Recipients.
Article in Circulation. Cardiovascular imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Cardiac magnetic resonance in heart transplant recipients: histological, clinical and cell-free DNA validation.European heart journal. Cardiovascular Imaging · 2025Trial
- Article
- Non-invasive imaging in heart transplant recipients: state of art and future direction.European journal of nuclear medicine and molecular imaging · 2026Review
- Dynamic cellular programs of human cardiac allograft rejection revealed by spatial transcriptomics.Nature cardiovascular research · 2026Article
- Lipofuscin: Wear Pigment or Alarm Signal for Cardiac AlloGraft Vasculopathy?Diagnostics (Basel, Switzerland) · 2026Article
- Fibrosis Process Activation in Patients with Acute Cardiac Rejection: A Novel Noninvasive Diagnostic Approach.Biomedicines · 2026Article
- The use of multimodality imaging in heart transplant recipients: a case series.European heart journal. Case reports · 2025Article
- Right Ventricular Function Score by Echocardiography for Predicting Outcomes After Heart Transplantation.Journal of the American Heart Association · 2025Article
- Utilizing cardiac magnetic resonance to assess the sequelae of prior rejection episodes on myocardium and correlation with clinical outcomes.JHLT open · 2025Article
- Role of Computed Tomography and Other Non-Invasive and Invasive Imaging Modalities in Cardiac Allograft Vasculopathy.Journal of cardiovascular development and disease · 2025Review
- Time-restricted feeding attenuated hypertension-induced cardiac remodeling by modulating autophagy levels in spontaneously hypertensive rats.Scientific reports · 2025Article
- Cardiac preservation usingFrontiers in cardiovascular medicine · 2025Article
- Cardiac Allograft Vasculopathy: A Focus on Advances in Diagnosis and Management.Methodist DeBakey cardiovascular journal · 2025Review
- Clinical determinants and biomarkers associated with cardiac fibrosis after heart transplantation as assessed by magnetic resonance: Size matters.International journal of cardiology. Heart & vasculature · 2024Article
- Right Ventricular Function on Cardiovascular Magnetic Resonance Imaging and Long-Term Outcomes in Stable Heart Transplant Recipients.Circulation. Cardiovascular imaging · 2024Article
- Late-gadolinium enhancement is common in older pediatric heart transplant recipients and is associated with lower ejection fraction.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- Immunosuppressive Agents-Effects on the Cardiovascular System and Selected Metabolic Aspects: A Review.Journal of clinical medicine · 2023Review
- Sudden cardiac death after heart transplantation: a population-based study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Imaging Coronary Allograft Vasculopathy with Cardiac PET and Cardiac MRI.Current cardiology reports · 2021Review
- Myocardial damage assessed by late gadolinium enhancement on cardiovascular magnetic resonance imaging in cancer patients treated with anthracyclines and/or trastuzumab.European heart journal. Cardiovascular Imaging · 2021Article
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9 authors at 3 institutions in 1 country.
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Abstract
backgroundMyocardial fibrosis is a well-described histopathologic feature in heart transplant recipients. Whether myocardial fibrosis in heart transplant recipients is independently associated with clinical outcomes is unclear. We sought to determine whether myocardial fibrosis on late gadolinium enhancement cardiovascular magnetic resonance imaging in heart transplant recipients was independently associated with all-cause death or major adverse cardiac outcomes in the long-term.
methodsUsing a cohort of consecutive heart transplant recipients that had cardiovascular magnetic resonance imaging, we determined the prevalence and the patterns of myocardial fibrosis and analyzed associations between myocardial fibrosis and a composite end point of all-cause death or major adverse cardiac events: retransplantation, nonfatal myocardial infarction, coronary revascularization, and heart failure hospitalization.
resultsOne hundred and fifty-two heart transplant recipients (age, 54±15 years; 29% women; 5.0±5.4 years after heart transplantation) were included. Myocardial fibrosis was present in 18% (37% infarct pattern, 41% noninfarct pattern, and 22% both). Its prevalence was positively associated with cardiac allograft vasculopathy grade. With a median follow-up of 2.6 years, myocardial fibrosis was independently associated with all-cause death or major adverse cardiac events (hazard ratio, 2.88; 95% CI, 1.59-5.23;
conclusionsIn heart transplant recipients, myocardial fibrosis is seen on late gadolinium enhancement cardiovascular magnetic resonance imaging in 18%. Both the presence and the extent of myocardial fibrosis are independently associated with the long-term risk of all-cause death or major adverse cardiac events.
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