ArticleJournal of pain and symptom management2020
Challenges in Implementing Hospice Clinical Trials: Preserving Scientific Integrity While Facing Change.
Article in Journal of pain and symptom management, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Perceived Benefits and Burdens of Participation for Caregivers of Cancer Patients in Hospice Clinical Trials: A Pilot Study.Journal of pain and symptom management · 2021Trial
- Addressing Statistical Power and Increasing Diversity in Hospice Research: Electronic Medical Record Participant Identification Compared to Nurse Referral Approaches to Recruitment.Journal of pain and symptom management · 2024Article
- Pain Management Education for Rural Hospice Family Caregivers: A Pilot Study With Embedded Implementation Evaluation.The American journal of hospice & palliative care · 2024Article
- Interventions for behavioral health comorbidities in the hospice setting: a scoping review.Annals of palliative medicine · 2024Article
- Interventions for Family Caregivers of Patients Receiving Palliative/Hospice Care at Home: A Scoping Review.Journal of palliative medicine · 2024Article
- Cancer-Related Fatigue in Hospice: A Nudge to Action?Journal of pain and symptom management · 2023Article
- Access for Cancer Caregivers to Education and Support for Shared Decision Making (ACCESS) intervention: a cluster cross-over randomised clinical trial.BMJ supportive & palliative care · 2023Article
- Older Adult Engagement With FacebookJournal of gerontological nursing · 2022Article
- The Lived Experience of Physical Separation for Hospice Patients and Families amid COVID-19.Journal of pain and symptom management · 2022Article
- A Goal-Directed Model of Collaborative Decision Making in Hospice and Palliative Care.Journal of palliative care · 2022Article
- Mixed methods analysis of hospice staff perceptions and shared decision making practices in hospice.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Pediatric Concurrent Hospice Care: A Scoping Review and Directions for Future Nursing Research.Journal of hospice and palliative nursing : JHPN : the official journal of the Hospice and Palliative Nurses Association · 2020Article
- Gaps in Hospice and Palliative Care Research: A Scoping Review of the North American Literature.Journal of aging research · 2020Article
- Facebook Online Support Groups for Hospice Family Caregivers of Advanced Cancer Patients: Protocol, Facilitation Skills and Promising Outcomes.Journal of social work in end-of-life & palliative careArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
BACKGROUND/
aimsNumerous changes can occur between the original design plans for clinical trials, the submission of funding proposals, and the implementation of the clinical trial. In the hospice setting, environmental changes can present significant obstacles, which require changes to the original plan designs, recruitment, and staffing. The purpose of the study was to share lessons and problem-solving strategies that can assist in future hospice trials.
methodsThis study uses one hospice clinical trial as an exemplar to demonstrate challenges for clinical trial research in this setting. Using preliminary data collected during the first months of a trial, the research team details the many ways their current protocol reflects changes from the originally proposed plans. Experiences are used as an exemplar to address the following questions: 1) How do research environments change between the initial submission of a funding proposal and the eventual award? 2) How can investigators maintain the integrity of the research and accommodate unexpected changes in the research environment?
resultsThe changing environment within the hospice setting required design, sampling, and recruitment changes within the first year. The decision-making process resulted in a stronger design with greater generalization. As a result of necessary protocol changes, the study results are positioned to be translational following the study conclusion.
conclusionResearchers would do well to review their protocol and statistics early in a clinical trial. They should be prepared for adjustments to accommodate market and environmental changes outside their control. Ongoing data monitoring, specifically related to recruitment, is advised.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.