Evidence map›Paper›PMID 31610175›Full record

ArticleThe American journal of pathology2020

Intestinal SIRT1 Deficiency Protects Mice from Ethanol-Induced Liver Injury by Mitigating Ferroptosis.

Zhou Zhou, Ting Jie Ye, Elizabeth DeCaro, Brian Buehler, Zachary Stahl, Gregory Bonavita, Michael Daniels, Min You

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 135 citations in OpenAlex.

  1. Ferroptosis in liver biology and diseases.Hepatology communications · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Fine Particulate Matter (Environmental health perspectives · 2025
    Article
  14. Review
  15. Review
  16. Frontiers in microbiology · 2025
    Article
  17. Potential role of SIRT1 in cell ferroptosis.Frontiers in cell and developmental biology · 2025
    Review
  18. Review
  19. Article
  20. Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Zhou ZhouCollege of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio.
Ting Jie YeCollege of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio; Department of Biology, School of Basic Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Elizabeth DeCaroCollege of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio.
Brian BuehlerCollege of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio.
Zachary StahlCollege of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio.
Gregory BonavitaCollege of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio.
Michael DanielsCollege of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio.
Min YouCollege of Pharmacy, Northeast Ohio Medical University, Rootstown, Ohio. Electronic address: myou@neomed.edu.
Northeast Ohio Medical University · USShanghai University of Traditional Chinese Medicine · CN

Funding

Project Two - Exercise Training Decreases Alcohol Drinking by an FGF21-Dependent MechanismP50AA024333 · NIAAA · CLEVELAND CLINIC LERNER COM-CWRU · PI LAURA E. NAGY · 2016 to 2026
$19.6M
ETHANOL REGULATION OF ADIPONECTIN AND ITS SIGNALINGR01AA015951 · NIAAA · UNIVERSITY OF SOUTH FLORIDA · PI FERRELL, JESSICA MARIE · 2006 to 2022
$5.0M
Effects of ethanol on lipid metabolismR01AA013623 · NIAAA · UNIVERSITY OF SOUTH FLORIDA · PI LEE, YOON-KWANG · 2003 to 2018
$4.6M
NIAAA NIH HHS P50 AA024333NIAAA NIH HHS R01 AA013623NIAAA NIH HHS R01 AA015951
6 · The paper itself

Abstract

Aberrant liver sirtuin 1 (SIRT1), a mammalian NAD

Indexed as

FerroptosisProtective AgentsAnimalsAnti-Infective Agents, LocalChemical and Drug Induced Liver InjuryDisease Models, AnimalEthanolFemaleInflammationIntestinesMiceMice, Inbred C57BLMice, KnockoutOxidative StressSignal TransductionSirtuin 1Anti-Infective Agents, LocalEthanolProtective AgentsSirt1 protein, mouseSirtuin 1

Identifiers

PMID31610175
PMCPMC6943377
OpenAlexW2979528321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.