Evidence map›Paper›PMID 31609783›Full record

ArticleThe American journal of surgical pathology2020

An Enteropathy-like Indolent NK-Cell Proliferation Presenting in the Female Genital Tract.

Rahul Krishnan, Kari Ring, Eli Williams, Craig Portell, Elaine S Jaffe, Alejandro A Gru

Open access · greenAbstract readCase Reports
In one paragraph

Article in The American journal of surgical pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Lymph node involvement by enteropathy-like indolent NK-cell proliferation.Virchows Archiv : an international journal of pathology · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Rahul KrishnanDepartments of Obstetrics & Gynecology.
Kari RingDepartments of Obstetrics & Gynecology.
Eli WilliamsPathology.
Craig PortellHematology/Oncology, University of Virginia, Charlottesville, VA.
Elaine S JaffeHematopathology Section, Laboratory of Pathology, National Institute of Health (NIH), Bethesda, MD.
Alejandro A GruPathology.
Beijing Obstetrics and Gynecology Hospital · CNNational Institutes of Health · USUniversity of Virginia · US

Funding

Hematopathology DiagnosisZIABC011070 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JAFFE, ELAINE · 2009 to 2025
$14.5M
Anatomic Pathology Residency ProgramZ01BC010684 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JAFFE, ELAINE · 2005 to 2008
$4.1M
Clinical Proteomics and Laser Capture MicrodissectionZ01BC010676 · NCI · BASIC SCIENCES · PI JAFFE, ELAINE S · 2005 to 2007
$1.0M
Hematopathology diagnosis and educationZ01BC011070 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JAFFE, ELAINE · 2008 to 2008
$737k
Intramural NIH HHS Z01 BC010676Intramural NIH HHS Z01 BC010684Intramural NIH HHS Z01 BC011070
6 · The paper itself

Abstract

Natural killer (NK) cell enteropathy is a lymphoproliferative disorder, initially described by Mansoor and colleagues, that presents in the gastrointestinal tract, and is often mistaken for extranodal NK/T-cell lymphoma on first assessment. This population of cells in this process have an NK-cell phenotype (CD3, CD56, CD2, CD7), lacks evidence of Epstein-Barr virus infection, has germline rearrangement of the T-cell receptor, and a very indolent clinical course. Indeed, many of such patients had been originally diagnosed as having an NK/T-cell lymphoma, and subsequently received chemotherapy. We report a unique case where an indolent lymphoproliferative disorder with features that resemble NK-cell enteropathy is encountered for the first time outside the gastrointestinal tract, specifically in the female genitourinary tract. We provide morphologic, immunophenotypic, and molecular documentation of such, in association with a completely indolent clinical behavior of this type of process.

Indexed as

Cell ProliferationAdultFemaleGenetic MarkersHumansIntestinal DiseasesKiller Cells, NaturalLymphoproliferative DisordersTreatment OutcomeVaginaVaginal DiseasesGenetic Markers

Identifiers

PMID31609783
PMCPMC7071997
OpenAlexW2981283243

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.