Observational studyClinical and translational gastroenterology2019
Detection of Liver Steatosis With a Novel Ultrasound-Based Technique: A Pilot Study Using MRI-Derived Proton Density Fat Fraction as the Gold Standard.
Observational study in Clinical and translational gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
78 citing papers in PubMed, 4 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- Diagnostic performance of ultrasound attenuation imaging in detecting hepatic steatosis.Journal of medical ultrasonics (2001) · 2026Pooled it
- KASL clinical practice guidelines for noninvasive tests to assess liver fibrosis in chronic liver disease.Clinical and molecular hepatology · 2024Guideline
- Accuracy of the ultrasound attenuation coefficient for the evaluation of hepatic steatosis: a systematic review and meta-analysis of prospective studies.Ultrasonography (Seoul, Korea) · 2022Pooled it
- Quantitative assessment of liver steatosis using ultrasound controlled attenuation parameter (Echosens).Journal of medical ultrasonics (2001) · 2021Pooled it
- The impact of a low-calorie, reduced-fat diet on liver attenuation imaging: a randomized clinical trial.Abdominal radiology (New York) · 2025Trial
- Prospective study of quantitative liver MRI in cystic fibrosis: feasibility and comparison to PUSH cohort ultrasound.Pediatric radiology · 2023Trial
- Effect of region of interest settings on diagnostic performance of attenuation imaging in hepatic steatosis.Journal of medical ultrasonics (2001) · 2026Article
- Attenuation imaging and hepatorenal index composite score for the noninvasive assessment of hepatic steatosis in chronic liver disease: a prospective multicenter study.Journal of medical ultrasonics (2001) · 2026Article
- Hepatic fat fraction and lipid content of adrenal adenomas: insights from unenhanced CT.Abdominal radiology (New York) · 2026Article
- Construction of a predictive model for the risk of non-alcoholic fatty liver disease in patients with sleep apnea syndrome based on multiple machine learning algorithms: a multicenter study.BMC medical informatics and decision making · 2026Article
- Ultrasound-based attenuation imaging for assessing steatosis severity in overweight/obese children: a prospective single-center study.Insights into imaging · 2026Article
- Non-invasive ultrasound assessment of chronic liver disease: current position and future directions for a "one-stop" liver ultrasound approach.Insights into imaging · 2026Article
- Exploring the association between BMI and liver fat in children: a study using ultrasound-derived fat fraction (UDFF).Pediatric radiology · 2026Article
- Evaluation methods of hepatic steatosis: From conventional techniques to emerging biomarkers.World journal of hepatology · 2026Review
- Diagnostic performance of controlled attenuation parameter for grading hepatic steatosis in MASLD: an MRI-PDFF-referenced study in a Chinese cohort.Frontiers in medicine · 2026Article
- Fat Content Quantification with US Attenuation Coefficient: Phantom Correlation with MRI Proton Density Fat Fraction.Diagnostics (Basel, Switzerland) · 2025Article
- Multiparametric Quantitative Ultrasound for Hepatic Steatosis: Comparison with CAP and Robustness Across Breathing States.Diagnostics (Basel, Switzerland) · 2025Article
- Prospective multicenter study on the reproducibility of ultrasound-derived fat fraction in assessing hepatic steatosis.Insights into imaging · 2025Article
- Consistency and reliability of ultrasound-derived fat fraction in hepatic steatosis assessment: influence of posture and breathing variations.BMC medical imaging · 2025Article
- Depth-Dependent Variability in Ultrasound Attenuation Imaging for Hepatic Steatosis: A Pilot Study of ATI and HRI in Healthy Volunteers.Journal of imaging · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe primary aim of this study was to investigate the value of attenuation imaging (ATI), a novel ultrasound technique for detection of steatosis, by comparing the results to that obtained with controlled attenuation parameter (CAP) and by using MRI-derived proton density fat fraction (PDFF) as reference standard.
methodsFrom March to November 2018, 114 consecutive adult subjects potentially at risk of steatosis and 15 healthy controls were enrolled. Each subject underwent ATI and CAP assessment on the same day. MRI-PDFF was performed within a week.
resultsThe prevalence of steatosis, as defined by MRI-PDFF ≥ 5%, was 70.7%. There was a high correlation of ATI with MRI-PDFF (r = 0.81, P < 0.0001). The correlation of CAP with MRI-PDFF and with ATI, respectively, was moderate (r = 0.65, P < 0.0001 and r = 0.61, P < 0.0001). The correlation of ATI or CAP with PDFF was not affected by age, gender, or body mass index. Area under the receiver operating characteristics of ATI and CAP, respectively, were 0.91 (0.84-0.95; P < 0.0001) and 0.85 (0.77-0.91; P < 0.0001) for detecting S > 0 steatosis (MRI-PDFF ≥ 5%); 0.95 (0.89-0.98; P < 0.0001) and 0.88 (0.81-0.93; P < 0.0001) for detecting S > 1 steatosis (MRI-PDFF ≥ 16.3%). The cutoffs of ATI and CAP, respectively, were 0.63 dB/cm/MHz and 258 dB/m for detecting S > 0 liver steatosis; 0.72 dB/cm/MHz and 304 dB/m for detecting S > 1 steatosis. ATI performed better than CAP, and this improvement was statistically significant for S > 1 (P = 0.04). DISCUSSION: This study shows that, in patients with no fibrosis/mild fibrosis, ATI is a very promising tool for the noninvasive assessment of steatosis.
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