Evidence map›Paper›PMID 31609579›Full record

ArticleACS chemical neuroscience2019

Location and Cell-Type-Specific Bias of Metabotropic Glutamate Receptor, mGlu

Yuh-Jiin Ivy Jong, Steven K Harmon, Karen L O'Malley

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Human CD4International journal of molecular sciences · 2022
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yuh-Jiin Ivy JongDepartment of Neuroscience , Washington University School of Medicine , Saint Louis , Missouri 63110 , United States.
Steven K HarmonDepartment of Neuroscience , Washington University School of Medicine , Saint Louis , Missouri 63110 , United States.
Karen L O'MalleyDepartment of Neuroscience , Washington University School of Medicine , Saint Louis , Missouri 63110 , United States.ORCID 0000-0002-3064-3774
Washington University in St. Louis · US

Funding

Washington University Intellectual and Developmental Disabilities Research Center-Administrative Down Syndrome SupplementU54HD087011 · NICHD · WASHINGTON UNIVERSITY · PI CONSTANTINO, JOHN N. · 2015 to 2019
$7.1M
Testing the role of intracellular vs. cell surface mGlu5 in models of synaptic plasticity using CRISPR-modified miceR01MH119197 · NIMH · WASHINGTON UNIVERSITY · PI O'MALLEY, KAREN L · 2020 to 2024
$1.6M
Expanding Access to Planar Illumination Microscopy in a Neuroimaging CoreR24NS086741 · NINDS · WASHINGTON UNIVERSITY · PI TAGHERT, PAUL H · 2014 to 2017
$814k
SELECTIVE ACTIONS OF MGLU5 RECEPTOR NEGATIVE ALLOSTERIC MODULATORSR21MH109019 · NIMH · WASHINGTON UNIVERSITY · PI O'MALLEY, KAREN L · 2016 to 2017
$419k
LOCATION-DEPENDENT SIGNALING OF MGLU5 IN MODELS OF SYNAPTIC PLASTICITY USING CRISPR-TARGETED MICER21NS102783 · NINDS · WASHINGTON UNIVERSITY · PI O'MALLEY, KAREN L · 2017 to 2018
$419k
NICHD NIH HHS U54 HD087011NIMH NIH HHS R01 MH119197NIMH NIH HHS R21 MH109019NINDS NIH HHS R21 NS102783NINDS NIH HHS R24 NS086741
6 · The paper itself

Abstract

Emerging data indicate that G-protein coupled receptor (GPCR) signaling is determined by not only the agonist and a given receptor but also a variety of cell-type-specific factors that can influence a receptor's response. For example, the metabotropic glutamate receptor, mGlu

Indexed as

Allosteric RegulationAnimalsAnimals, NewbornBrainCells, CulturedHEK293 CellsHumansIndolesIsoxazolesRatsReceptor, Metabotropic Glutamate 5TriazolesAZD2066IndolesIsoxazolesmavoglurantReceptor, Metabotropic Glutamate 5TriazolescalciumGPCRintracellularmGlu5NAMneuron

Identifiers

PMID31609579
PMCPMC8753982
OpenAlexW2981263508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.