Observational studyArthritis care & research2020
Rheumatoid Arthritis Flares After Total Hip and Total Knee Arthroplasty: Outcomes at One Year.
Observational study in Arthritis care & research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Revision Risk Following Total Hip Arthroplasty in Patients With Rheumatoid Arthritis: A Cohort Study From the Australian Orthopaedic Association National Joint Replacement Registry.ANZ journal of surgery · 2026Article
- The Impact of Preoperative Inflammatory Activity in Patients with Ankylosing Spondylitis on Postoperative Joint Function: A Retrospective Cohort Study.Journal of inflammation research · 2026Article
- Clinical Outcomes of Methotrexate Usage in Postoperative Arthroplasty Patients: An Evidence Based Review.Orthopedic research and reviews · 2025Review
- New evidence on patella resurfacing in modern total knee arthroplasty for all inflammatory arthritis in a mixed Asian population.Journal of clinical orthopaedics and trauma · 2024Article
- A Meta-Analysis Examining the Effect of Perioperative Biologic Disease-Modifying Anti-Rheumatic Medications on Postoperative Wound Complications in Various Orthopedic Surgeries.Journal of clinical medicine · 2024Review
- Article
- Machine learning identification of thresholds to discriminate osteoarthritis and rheumatoid arthritis synovial inflammation.Arthritis research & therapy · 2023Article
- [Perioperative management of treatment of patients with inflammatory rheumatic diseases : Updated recommendations of the German Society of Rheumatology].Zeitschrift fur Rheumatologie · 2022Article
- Risk factor analysis of perioperative complications in patients with rheumatoid arthritis undergoing primary cervical spine surgery.Arthritis research & therapy · 2022Article
- The Causal Relationship Between Rheumatoid Arthritis and Mechanical Complications of Prosthesis After Arthroplasty: A Two-Sample Mendelian Randomization Study.Frontiers in genetics · 2022Article
- Article
- Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveMost patients with rheumatoid arthritis (RA) undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA) have active RA and report postoperative flares; whether RA disease activity or flares increase the risk of worse pain and function scores 1 year later is unknown.
methodsPatients with RA were enrolled before THA/TKA. Patient-reported outcomes, including the Hip disability and Osteoarthritis Outcome Score (HOOS)/Knee Injury and Osteoarthritis Outcome Score (KOOS) and physician assessments of disease characteristics and activity (Disease Activity Score in 28 joints [DAS28] and Clinical Disease Activity Index), were collected before surgery. Patient-reported outcomes were repeated at 1 year. Postoperative flares were identified using the RA Flare Questionnaire weekly for 6 weeks and were defined by concordance between patient report plus physician assessment. We compared baseline characteristics and HOOS/KOOS scores using 2-sample t-test/Wilcoxon's rank sum test as well as chi-square/Fisher's exact tests. We used multivariate linear and logistic regression to determine the association of baseline characteristics, disease activity, and flares with 1-year outcomes.
resultsOne-year HOOS/KOOS scores were available for 122 patients (56 with THA and 66 with TKA). Although HOOS/KOOS pain was worse for patients who experienced a flare within 6 weeks of surgery, absolute improvement was not different. In multivariable models, baseline DAS28 predicted 1-year HOOS/KOOS pain and function; each 1-unit increase in DAS28 worsened 1-year pain by 2.41 (SE 1.05; P = 0.02) and 1-year function by 4.96 (SE 1.17; P = 0.0001). Postoperative flares were not independent risk factors for pain or function scores.
conclusionHigher disease activity increased the risk of worse pain and function 1 year after arthroplasty, but postoperative flares did not.
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