Evidence map›Paper›PMID 31609499›Full record

ArticleBrain pathology (Zurich, Switzerland)2020

Myxoid glioneuronal tumor, PDGFRA p.K385-mutant: clinical, radiologic, and histopathologic features.

Calixto-Hope G Lucas, Javier E Villanueva-Meyer, Nicholas Whipple, Nancy Ann Oberheim Bush, Tabitha Cooney, Susan Chang, Michael McDermott, Mitchel Berger, Elaine Cham, Peter P Sun and 25 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.

  1. Guideline
  2. Intraoperative diagnosis of myxoid glioneuronal tumor guiding safe limited resection: a case report.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026
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  11. Review
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  13. Myxoid glioneuronal tumor of the septum pellucidum in pediatric patients: a case report and comprehensive review of the literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Review
  14. Imaging of pediatric glioneuronal and neuronal tumors.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Review
  15. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 7 institutions in 1 country.

Calixto-Hope G LucasDepartment of Pathology, University of California, San Francisco, CA.ORCID 0000-0002-8347-9592
Javier E Villanueva-MeyerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, CA.
Nicholas WhippleDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of Utah, Salt Lake City, UT.
Nancy Ann Oberheim BushDivision of Neuro-Oncology, Department of Neurological Surgery, University of California, San Francisco, CA.
Tabitha CooneyDivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of California, San Francisco, CA.
Susan ChangDivision of Neuro-Oncology, Department of Neurological Surgery, University of California, San Francisco, CA.
Michael McDermottDepartment of Neurological Surgery, University of California, San Francisco, CA.
Mitchel BergerDepartment of Neurological Surgery, University of California, San Francisco, CA.
Elaine ChamDepartment of Pathology, UCSF Benioff Children's Hospital Oakland, Oakland, CA.
Peter P SunDepartment of Neurosurgery, UCSF Benioff Children's Hospital Oakland, Oakland, CA.
Angelica PutnamDepartment of Pathology, University of Utah, Salt Lake City, UT.
Hong ZhouDepartment of Pathology, University of Utah, Salt Lake City, UT.
Robert BolloDivision of Pediatric Neurosurgery, Department of Neurosurgery, University of Utah, Salt Lake City, UT.
Samuel CheshierDivision of Pediatric Neurosurgery, Department of Neurosurgery, University of Utah, Salt Lake City, UT.
Matthew M PoppeDepartment of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT.
Kar-Ming FungDepartment of Pathology, University of Oklahoma, Oklahoma City, OK.
Sarah SungDepartment of Neurology, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Chad GlennDepartment of Neurosurgery, Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Xuemo FanDepartment of Pathology, Cedars Sinai Medical Center, Los Angeles, CA.
Serguei BannykhDepartment of Pathology, Cedars Sinai Medical Center, Los Angeles, CA.
Jethro HuDepartment of Neurology, Cedars Sinai Medical Center, Los Angeles, CA.
Moise DanielpourDepartment of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA.
Rong LiDepartment of Pathology, Children's Hospital of Alabama, Birmingham, AL.
Elizabeth AlvaDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Children's Hospital of Alabama, Birmingham, AL.
James JohnstonDepartment of Neurosurgery, Children's Hospital of Alabama, Birmingham, AL.
Jessica Van ZiffleDepartment of Pathology, University of California, San Francisco, CA.
Courtney OnoderaDepartment of Pathology, University of California, San Francisco, CA.
Patrick DevineDepartment of Pathology, University of California, San Francisco, CA.
James P GrenertDepartment of Pathology, University of California, San Francisco, CA.
Julieann C LeeDepartment of Pathology, University of California, San Francisco, CA.ORCID 0000-0003-0138-4862
Melike PekmezciDepartment of Pathology, University of California, San Francisco, CA.
Tarik TihanDepartment of Pathology, University of California, San Francisco, CA.
Andrew W BollenDepartment of Pathology, University of California, San Francisco, CA.
Arie PerryDepartment of Pathology, University of California, San Francisco, CA.ORCID 0000-0002-8300-7261
David A SolomonDepartment of Pathology, University of California, San Francisco, CA.ORCID 0000-0003-4571-7999
University of California, San Francisco · USUniversity of Utah · USCedars-Sinai Medical Center · USChildren's of Alabama · USUCSF Benioff Children's Hospital · USUniversity of Oklahoma Health Sciences Center · USOklahoma City University · US

Funding

Cohesin gene mutations in tumorigenesisDP5OD021403 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOLOMON, DAVID A. · 2015 to 2019
$2.0M
NIH HHS DP5 OD021403
6 · The paper itself

Abstract

"Myxoid glioneuronal tumor, PDGFRA p.K385-mutant" is a recently described tumor entity of the central nervous system with a predilection for origin in the septum pellucidum and a defining dinucleotide mutation at codon 385 of the PDGFRA oncogene replacing lysine with either leucine or isoleucine (p.K385L/I). Clinical outcomes and optimal treatment for this new tumor entity have yet to be defined. Here, we report a comprehensive clinical, radiologic, and histopathologic assessment of eight cases. In addition to its stereotypic location in the septum pellucidum, we identify that this tumor can also occur in the corpus callosum and periventricular white matter of the lateral ventricle. Tumors centered in the septum pellucidum uniformly were associated with obstructive hydrocephalus, whereas tumors centered in the corpus callosum and periventricular white matter did not demonstrate hydrocephalus. While multiple patients were found to have ventricular dissemination or local recurrence/progression, all patients in this series remain alive at last clinical follow-up despite only biopsy or subtotal resection without adjuvant therapy in most cases. Our study further supports "myxoid glioneuronal tumor, PDGFRA p.K385-mutant" as a distinct CNS tumor entity and expands the spectrum of clinicopathologic and radiologic features of this neoplasm.

Indexed as

MutationAdolescentAdultAgedBrain NeoplasmsCerebral Ventricle NeoplasmsChildCorpus CallosumFemaleGliomaHigh-Throughput Nucleotide SequencingHumansLateral VentriclesMagnetic Resonance ImagingMaleReceptor, Platelet-Derived Growth Factor alphaReceptor, Platelet-Derived Growth Factor alphacorpus callosumDNT-like tumor of the septum pellucidumdysembryoplastic neuroepithelial tumor (DNT)lateral ventriclemolecular neuro-oncologymolecular neuropathologymyxoid glioneuronal tumorPDGFRAperiventricular white matterplatelet-derived growth factor receptor alphaseptal DNTseptum pellucidum

Identifiers

PMID31609499
PMCPMC7780370
OpenAlexW2981098618

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.