Evidence map›Paper›PMID 31609469›Full record

ArticleThe Journal of comparative neurology2020

Expression of protocadherin-γC4 protein in the rat brain.

Celia P Miralles, Michael J Taylor, John Bear, Christopher D Fekete, Shanu George, Yanfang Li, Bevan Bonhomme, Tzu-Ting Chiou, Angel L De Blas

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of comparative neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Celia P MirallesDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
Michael J TaylorDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
John BearDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
Christopher D FeketeDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
Shanu GeorgeDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
Yanfang LiDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
Bevan BonhommeDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
Tzu-Ting ChiouDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.
Angel L De BlasDepartment of Physiology and Neurobiology, University of Connecticut, Storrs, Connecticut, USA.ORCID 0000-0002-0545-5069
University of Connecticut · US

Funding

GABAA RECEPTOR - INTERACTING PROTEINSR01NS038752 · NINDS · UNIVERSITY OF CONNECTICUT STORRS · PI DE BLAS, ANGEL L · 2000 to 2014
$4.1M
NINDS NIH HHS R01 NS038752
6 · The paper itself

Abstract

It has been proposed that the combinatorial expression of γ-protocadherins (Pcdh-γs) and other clustered protocadherins (Pcdhs) provides a code of molecular identity and individuality to neurons, which plays a major role in the establishment of specific synaptic connectivity and formation of neuronal circuits. Particular attention has been directed to the Pcdh-γ family, for which experimental evidence derived from Pcdh-γ-deficient mice shows that they are involved in dendrite self-avoidance, synapse development, dendritic arborization, spine maturation, and prevention of apoptosis of some neurons. Moreover, a triple-mutant mouse deficient in the three C-type members of the Pcdh-γ family (Pcdh-γC3, Pcdh-γC4, and Pcdh-γC5) shows a phenotype similar to the mouse deficient in whole Pcdh-γ family, indicating that the latter is largely due to the absence of C-type Pcdh-γs. The role of each individual C-type Pcdh-γ is not known. We have developed a specific antibody to Pcdh-γC4 to reveal the expression of this protein in the rat brain. The results show that although Pcdh-γC4 is expressed at higher levels in the embryo and earlier postnatal weeks, it is also expressed in the adult rat brain. Pcdh-γC4 is expressed in both neurons and astrocytes. In the adult brain, the regional distribution of Pcdh-γC4 immunoreactivity is similar to that of Pcdh-γC4 mRNA, being highest in the olfactory bulb, dentate gyrus, and cerebellum. Pcdh-γC4 forms puncta that are frequently apposed to glutamatergic and GABAergic synapses. They are also frequently associated with neuron-astrocyte contacts. The results provide new insights into the cell recognition function of Pcdh-γC4 in neurons and astrocytes.

Indexed as

AnimalsAstrocytesBrainCadherin Related ProteinsCadherinsFemaleMaleMiceNeuronsRatsRats, Sprague-DawleyCadherin Related ProteinsCadherinsGamma-protocadherinsastrocytescell-cell recognitionGABAergic synapseglutamatergic synapseneuron-astrocyte interactionprotocadherinsRRID:AB_10672982RRID:AB_10676098RRID:AB_1279448RRID:AB_2092365RRID:AB_2223041RRID:AB_2259153RRID:AB_2301751RRID:AB_2313650RRID:AB_2314493RRID:AB_477499RRID:AB_887873synapse formation

Identifiers

PMID31609469
PMCPMC6987019
OpenAlexW2980621023

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.