Evidence map›Paper›PMID 31609421›Full record

ArticleBioinformatics (Oxford, England)2020

Mat_peptide: comprehensive annotation of mature peptides from polyproteins in five virus families.

Christopher N Larsen, Guangyu Sun, Xiaomei Li, Sam Zaremba, Hongtao Zhao, Sherry He, Liwei Zhou, Sanjeev Kumar, Vince Desborough, Edward B Klem

Open access · bronzeAbstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Christopher N LarsenVecna Technologies, Inc., Greenbelt, MD 20770.
Guangyu SunVecna Technologies, Inc., Greenbelt, MD 20770.
Xiaomei LiNorthrop Grumman, Rockville, MD 20850, USA.
Sam ZarembaNorthrop Grumman, Rockville, MD 20850, USA.
Hongtao ZhaoNorthrop Grumman, Rockville, MD 20850, USA.
Sherry HeNorthrop Grumman, Rockville, MD 20850, USA.
Liwei ZhouNorthrop Grumman, Rockville, MD 20850, USA.
Sanjeev KumarNorthrop Grumman, Rockville, MD 20850, USA.
Vince DesboroughNorthrop Grumman, Rockville, MD 20850, USA.
Edward B KlemNorthrop Grumman, Rockville, MD 20850, USA.
Northrop Grumman (United States) · USVecna Technologies (United States) · US

Funding

NIAID NIH HHS HHSN272201400028C
6 · The paper itself

Abstract

motivationSequence repositories have few well-annotated virus mature peptide sequences. Therefore post-translational proteolytic processing of polyproteins into mature peptides (MPs) has been performed in silico, with a new computational method, for over 200 species in 5 pathogenic virus families (Caliciviridae, Coronaviridae, Flaviviridae, Picornaviridae and Togaviridae).

resultsUsing pairwise alignment with reference sequences, MPs have been annotated and their sequences made available for search, analysis and download. At publication the method had produced 156 216 sequences, a large portion of the protein sequences now available in https://www.viprbrc.org. It represents a new and comprehensive mature peptide collection. AVAILABILITY AND IMPLEMENTATION: The data are available at the Virus Pathogen Resource https://www.viprbrc.org, and the software at https://github.com/VirusBRC/vipr_mat_peptide.

Indexed as

PolyproteinsVirusesAmino Acid SequencePeptidesSoftwarePeptidesPolyproteins

Identifiers

PMID31609421
PMCPMC8215913
OpenAlexW2980668222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.