Evidence map›Paper›PMID 31609353›Full record

ArticleJournal of visualized experiments : JoVE2019

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice.

Xiaofang Xiong, Fengyang Lei, Mohammad Haque, Jianxun Song

Open access · greenAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of visualized experiments : JoVE, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Xiaofang XiongDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center.
Fengyang LeiDepartment of Ophthalmology, Harvard Medical School.
Mohammad HaqueDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center.
Jianxun SongDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center; jus35@tamu.edu.
Texas A&M Health Science Center · USHarvard University · US

Funding

Nucleus Accumbens-Associated Protein-1 in Melanoma ImmunotherapyR01CA221867 · NCI · UNIVERSITY OF KENTUCKY · PI SONG, JIANXUN JIM, YANG, JIN-MING · 2018 to 2023
$2.8M
Stem cell-derived regulatory T cells for therapeutic use in arthritisR01AI121180 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SONG, JIANXUN JIM · 2016 to 2020
$1.9M
Directed differentiation of HBV-specific CTL from iPSC for cell-based therapiesR21AI109239 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI SONG, JIANXUN JIM · 2014 to 2015
$441k
Role of stem cell-derived T lymphocytes in chronic HBV infectionR21AI128325 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SONG, JIANXUN JIM · 2017 to 2018
$419k
NCI NIH HHS R01 CA221867NIAID NIH HHS R01 AI121180NIAID NIH HHS R21 AI109239NIAID NIH HHS R21 AI128325
6 · The paper itself

Abstract

Hepatitis B virus (HBV) infection is a global health issue. With over 350 million people affected worldwide, HBV infection remains the leading cause of liver cancer. This is a major concern, especially in developing countries. Failure of the immune system to mount an effective response against HBV leads to chronic infection. Although HBV vaccine is present and novel antiviral medicines are being created, eradication of virus-reservoir cells remains a major health topic. Described here is a method for the generation of viral antigen (Ag) -specific CD8

Indexed as

AnimalsAntigens, ViralCD8-Positive T-LymphocytesDisease Models, AnimalFemaleHepatitis B virusHydrodynamicsImmunotherapyInduced Pluripotent Stem CellsMice, TransgenicT-LymphocytesVirus ReplicationAntigens, Viral

Identifiers

PMID31609353
PMCPMC7194242
OpenAlexW2976481606

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.