Evidence map›Paper›PMID 31609340›Full record

ArticleJournal of visualized experiments : JoVE2019

Cell Type-specific Gene Expression Profiling in the Mouse Liver.

Amber W Wang, Adam M Zahm, Kirk J Wangensteen

Open access · greenAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of visualized experiments : JoVE, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Amber W WangDepartment of Genetics, University of Pennsylvania.
Adam M ZahmDepartment of Genetics, University of Pennsylvania.
Kirk J WangensteenDepartment of Genetics, University of Pennsylvania; Department of Medicine, University of Pennsylvania; wkirk@upenn.edu.
University of Pennsylvania · US

Funding

TRANSGENIC AND CHIMERIC MOUSE COREP30DK050306 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI REBECCA G WELLS · 1997 to 2026
$32.5M
Genetic basis of liver repopulationK08DK106478 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI WANGENSTEEN, KIRK J · 2015 to 2019
$787k
Role of microRNAs in pediatric inflammatory bowel diseaseK01DK102868 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI ZAHM, ADAM MATTHEW · 2015 to 2019
$665k
Elucidating Redox Regulation in the Repopulating LiverF31DK113666 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI WANG, AMBER WEICHING · 2017 to 2019
$94k
NIDDK NIH HHS F31 DK113666NIDDK NIH HHS K01 DK102868NIDDK NIH HHS K08 DK106478NIDDK NIH HHS P30 DK050306
6 · The paper itself

Abstract

Liver repopulation after injury is a crucial feature of mammals which prevents immediate organ failure and death after exposure of environmental toxins. A deeper understanding of the changes in gene expression that occur during repopulation could help identify therapeutic targets to promote the restoration of liver function in the setting of injuries. Nonetheless, methods to isolate specifically the repopulating hepatocytes are inhibited by a lack of cell markers, limited cell numbers, and the fragility of these cells. The development of translating ribosome affinity purification (TRAP) technology in conjunction with the Fah

Indexed as

Gene Expression ProfilingAnimalsGreen Fluorescent ProteinsHepatocytesLiverMiceRibosomal ProteinsRNA, MessengerGreen Fluorescent ProteinsRibosomal ProteinsRNA, Messenger

Identifiers

PMID31609340
PMCPMC7507956
OpenAlexW2974457488

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.