Evidence map›Paper›PMID 31609300›Full record

ArticleMedicine and science in sports and exercise2020

Interval Exercise Lowers Circulating CD105 Extracellular Vesicles in Prediabetes.

Natalie Z M Eichner, Nicole M Gilbertson, Emily M Heiston, Luca Musante, Sabrina LA Salvia, Arthur Weltman, Uta Erdbrugger, Steven K Malin

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine and science in sports and exercise, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06546085 (Extracellular Vesicles, Insulin Action, and Exercise on Vascular Function in Type 2 Diabetes), which is not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06546085 narecruitingnot on this mapstarted 2025, after this paper: background citation

Extracellular Vesicles, Insulin Action, and Exercise on Vascular Function in Type 2 Diabetes

TypeinterventionalSponsorRutgers, The State University of New JerseyRan2025 to 2029Enrolled60ConditionsType 2 Diabetes, ObesityArmsExercise
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. The Mechanisms of the Development of Atherosclerosis in Prediabetes.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Natalie Z M EichnerDepartment of Kinesiology, University of Virginia, Charlottesville, VA.
Nicole M GilbertsonDepartment of Kinesiology, University of Virginia, Charlottesville, VA.
Emily M HeistonDepartment of Kinesiology, University of Virginia, Charlottesville, VA.
Luca MusanteDivision of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA.
Sabrina LA SalviaDivision of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA.
Arthur Weltman
Uta ErdbruggerDivision of Nephrology, University of Virginia, Charlottesville, VA.
Steven K Malin
University of Virginia · US

Funding

Exercise Dose and Metformin for Vascular Health in Adults with Metabolic SyndromeR01HL130296 · NHLBI · UNIVERSITY OF VIRGINIA · PI MALIN, STEVEN K · 2017 to 2021
$3.7M
NHLBI NIH HHS R01 HL130296
6 · The paper itself

Abstract

backgroundExtracellular vesicles (EV) are purported to mediate type 2 diabetes and CVD risk and development. Physical activity and a balanced diet reduce disease risk, but no study has tested the hypothesis that short-term interval (INT) training would reduce EV compared with continuous (CONT) exercise in adults with prediabetes.

methodsEighteen obese adults (age, 63.8 ± 1.5 yr; body mass index, 31.0 ± 1.3 kg·m) were screened for prediabetes using American Diabetes Association criteria (75 g oral glucose tolerance test). Subjects were randomized to INT (n = 10, alternating 3-min intervals at 90% and 50% HRpeak, respectively) or CONT (n = 8, 70% HRpeak) training for 12 supervised sessions over 13 d for 60 min·d. Cardiorespiratory fitness (V˙ O2peak), weight (kg), as well as ad libitum dietary intake were assessed and arterial stiffness (augmentation index via applanation tonometry) was calculated using total AUC during a 75-g oral glucose tolerance test performed 24 h after the last exercise bout. Total EV, platelet EV (CD31/CD41), endothelial EV (CD105; CD31/ CD41), platelet endothelial cell adhesion molecule (PECAM) (CD31), and leukocyte EV (CD45; CD45/CD41) were analyzed via imaging flow cytometry preintervention/postintervention.

resultsThe INT exercise increased V˙O2peak (P = 0.04) compared with CONT training. Although training had no effect on platelet or leukocyte EV, INT decreased Annexin V- endothelial EV CD105 compared with CONT (P = 0.04). However, after accounting for dietary sugar intake, the intensity effect was lost (P = 0.18). Increased ad libitum dietary sugar intake after training was linked to elevated AV+ CD105 (r = 0.49, P = 0.06) and AV- CD45 (r = 0.59, P = 0.01). Nonetheless, increased V˙O2peak correlated with decreased AV+ CD105 (r = -0.60, P = 0.01).

conclusionsInterval exercise training decreases endothelial-derived EV in adults with prediabetes. Although increased sugar consumption may alter EV after a short-term exercise intervention, fitness modifies EV count.

Indexed as

High-Intensity Interval TrainingBlood GlucoseBody Mass IndexCardiorespiratory FitnessDietEndoglinExercise TherapyExtracellular VesiclesHumansMiddle AgedObesityPrediabetic StateVascular StiffnessBlood GlucoseEndoglinENG protein, human

Identifiers

PMID31609300
PMCPMC7024030
OpenAlexW2979838126

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.