Evidence map›Paper›PMID 31609202›Full record

ArticleeLife2019

Synaptic mitochondria regulate hair-cell synapse size and function.

Hiu-Tung C Wong, Qiuxiang Zhang, Alisha J Beirl, Ronald S Petralia, Ya-Xian Wang, Katie Kindt

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 86 citations in OpenAlex.

  1. Article
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  7. Strengthening Medial Olivocochlear Feedback Reduces the Developmental Impact of Early Noise Exposure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. SKOOTS: Skeleton-oriented object segmentation for mitochondria.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Article
  11. Gating of hair cell CaScience advances · 2025
    Article
  12. Article
  13. A non-conducting role of the CabioRxiv : the preprint server for biology · 2024
    Article
  14. Article
  15. Article
  16. Article
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Hiu-Tung C WongSection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.ORCID 0000-0001-5826-8526
Qiuxiang ZhangSection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.
Alisha J BeirlSection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.
Ronald S PetraliaAdvanced Imaging Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.
Ya-Xian WangAdvanced Imaging Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.
Katie KindtSection on Sensory Cell Development and Function, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.ORCID 0000-0002-1065-8215
National Institutes of Health · US

Funding

In vivo investigation of sensory hair cell function and developmentZIADC000085 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI KINDT, KATIE · 2014 to 2025
$21.4M
Advanced Imaging CoreZICDC000081 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI WINKLER, DENNIS · 2012 to 2025
$17.4M
Intramural NIH HHS ZIA DC000085Intramural NIH HHS ZIC DC000081NIDCD NIH HHS 1ZIADC000085-01NIDCD NIH HHS ZICDC000081
6 · The paper itself

Abstract

Sensory hair cells in the ear utilize specialized ribbon synapses. These synapses are defined by electron-dense presynaptic structures called ribbons, composed primarily of the structural protein Ribeye. Previous work has shown that voltage-gated influx of Ca

Indexed as

3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl esterAnimalsAnimals, Genetically ModifiedCalciumCalcium Channel AgonistsCalcium Channel BlockersCalcium Channels, L-TypeCalcium SignalingCell SizeEmbryo, NonmammalianEvoked Potentials, AuditoryEye ProteinsGene ExpressionHair Cells, AuditoryIsradipineMitochondria3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl estercacna1da protein, zebrafishCalciumCalcium Channel AgonistsCalcium Channel BlockersCalcium Channels, L-Typectbp2a protein, zebrafishEye ProteinsIsradipineNADRu 360Ruthenium CompoundsZebrafish Proteinsdevelopmental biologymetabolismmitochondrial calciumneuroscienceribbon synapsesensory cellzebrafish

Identifiers

PMID31609202
PMCPMC6879205
OpenAlexW2979887709

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.