Evidence map›Paper›PMID 31608789›Full record

ArticlePhysiological genomics2019

Germ-line genetic variation in the immunoglobulin heavy chain creates stroke susceptibility in the spontaneously hypertensive rat.

Isha S Dhande, Sterling C Kneedler, Aniket S Joshi, Yaming Zhu, M John Hicks, Scott E Wenderfer, Michael C Braun, Peter A Doris

Open access · bronzeAbstract read
In one paragraph

Article in Physiological genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Journal of the American Heart Association · 2020
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Isha S DhandeInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas.
Sterling C KneedlerInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas.
Aniket S JoshiInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas.
Yaming ZhuInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas.
M John HicksDepartment of Pathology and Immunology, Baylor College of Medicine and Texas Children's Hospital, Houston.
Scott E WenderferDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas.ORCID 0000-0002-8991-8277
Michael C BraunDepartment of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas.
Peter A DorisInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas.
The University of Texas Health Science Center at Houston · USBaylor College of Medicine · US

Funding

Hypertensive Renal InjuryR01DK081866 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DORIS, PETER A · 2009 to 2017
$2.9M
HNF1 transcriptional control of renal oxidative stressR01DK069632 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DORIS, PETER A · 2005 to 2009
$1.4M
Immunogenetics of common polygenic renal diseaseR01DK114235 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DORIS, PETER A · 2017 to 2020
$1.4M
Hypertensive Renal InjuryR56DK081866 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DORIS, PETER A · 2012 to 2012
$100k
NIDDK NIH HHS R01 DK069632NIDDK NIH HHS R01 DK081866NIDDK NIH HHS R01 DK114235NIDDK NIH HHS R56 DK081866
6 · The paper itself

Abstract

The risk of cerebrovascular disease in stroke-prone spontaneously hypertensive rats (SHR-A3/SHRSP) arises from naturally occurring genetic variation. In the present study we show the involvement of SHR genetic variation that affects antibody formation and function in the pathogenesis of stroke. We have tested the involvement in susceptibility to stroke of genetic variation in

Indexed as

Polymorphism, Single NucleotideAnimalsAnimals, CongenicAutoantibodiesGenetic Predisposition to DiseaseGerm CellsHaplotypesHSP70 Heat-Shock ProteinsHypertensionImmunoglobulin GImmunoglobulin Heavy ChainsImmunoglobulin MMaleRatsRats, Inbred SHRStrokeAutoantibodiesHSP70 Heat-Shock ProteinsImmunoglobulin GImmunoglobulin Heavy ChainsImmunoglobulin MHSP70hypertensionimmunoglobulinSHRSPstroke

Identifiers

PMID31608789
PMCPMC6879812
OpenAlexW2980666226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.