Evidence map›Paper›PMID 31608537›Full record

Trial reportCancer science2019

Phase II study of nab-paclitaxel + carboplatin for patients with non-small-cell lung cancer and interstitial lung disease.

Hirotsugu Kenmotsu, Kiyotaka Yoh, Keita Mori, Akira Ono, Tomohisa Baba, Yutaka Fujiwara, Ou Yamaguchi, Ryo Ko, Hiroaki Okamoto, Nobuyuki Yamamoto and 3 more

Open access · goldAbstract readClinical Trial, Phase IIMulticenter Study
In one paragraph

Trial report in Cancer science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Review
  8. Drug-Induced Interstitial Lung Disease in Lung Cancer Patients.Respiration; international review of thoracic diseases · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. [Research Progress of Anti-lung Cancer Drug-related Interstitial Lung Disease].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025
    Review
  18. TheJournal of clinical medicine · 2024
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 9 institutions in 1 country.

Hirotsugu KenmotsuDivision of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.ORCID https://orcid.org/0000-0003-0590-9259
Kiyotaka YohDepartment of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
Keita MoriClinical Trial Coordination Office, Shizuoka Cancer Center, Shizuoka, Japan.
Akira OnoDivision of Thoracic Oncology, Shizuoka Cancer Center, Shizuoka, Japan.
Tomohisa BabaDepartment of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
Yutaka FujiwaraDepartment of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan.ORCID https://orcid.org/0000-0001-6981-0800
Ou YamaguchiDepartment of Respiratory Medicine, Saitama Medical University International Medical Center, Saitama, Japan.
Ryo KoDepartment of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Hiroaki OkamotoDepartment of Respiratory Medicine and Medical Oncology, Yokohama Municipal Citizen's Hospital, Yokohama, Japan.
Nobuyuki YamamotoThird Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan.
Takashi NinomiyaDepartment of Respiratory Medicine and Allergy, Okayama University Hospital, Okayama, Japan.
Takashi OguraDepartment of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan.
Terufumi KatoDivision of Thoracic Oncology, Kanagawa Cancer Center, Yokohama, Japan.
Shizuoka Cancer Center · JPKanagawa Cardiovascular and Respiratory Center · JPJuntendo University · JPKanagawa Prefectural Hospital Organization · JPNational Cancer Center Hospital East · JPOkayama University Hospital · JPSaitama International Medical Center · JPWakayama Medical University · JPYokohama Municipal Citizen's Hospital · JP

Funding

Ministry of Health, Labour and Welfare
6 · The paper itself

Abstract

The prognosis of non-small-cell lung cancer (NSCLC) patients with interstitial lung disease (ILD) is poor, and 5%-20% of those receiving chemotherapy experience ILD exacerbation. To evaluate the safety and efficacy of nab-paclitaxel plus carboplatin for NSCLC patients with ILD, we undertook a multicenter phase II study. Chemotherapy-naïve patients with advanced NSCLC and mild or moderate ILD received nab-paclitaxel (100 mg/m

Indexed as

AgedAged, 80 and overAlbuminsAntineoplastic Combined Chemotherapy ProtocolsCarboplatinCarcinoma, Non-Small-Cell LungFemaleHumansLung Diseases, InterstitialLung NeoplasmsMaleMiddle AgedPaclitaxelProspective Studies130-nm albumin-bound paclitaxelAlbuminsCarboplatinPaclitaxelcarboplatinexacerbationinterstitial lung diseasenab-paclitaxelnon-small-cell lung cancer

Identifiers

PMID31608537
PMCPMC6890441
OpenAlexW2980903145

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.