ArticleInternational journal of geriatric psychiatry2020
The association between, depression, anxiety, and mortality in older people across eight low- and middle-income countries: Results from the 10/66 cohort study.
Article in International journal of geriatric psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Late-life depression and risk of all-cause and cause-specific mortality in an Asian population: the Singapore Chinese Health Study.BMJ public health · 2026Article
- Health outcomes across socioeconomic strata B, C, and DE among Brazilian adults living in moderate social vulnerability.Frontiers in psychiatry · 2026Article
- All-cause and cause-specific mortality in people with depression: a large-scale systematic review and meta-analysis of relative risk and aggravating or attenuating factors, including antidepressant treatment.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Psychological Distress in Older Adults Living in Puerto Rico during COVID-19.Journal of cross-cultural gerontology · 2025Article
- Dose-response relationship between sedentary time and anxiety and the moderating effect of a 10-min walk: a cross-sectional study.BMC psychiatry · 2025Article
- Cheers to anxiety: Granger causality insights on alcohol consumption patterns across 13 South American countries.BMC public health · 2024Article
- Prospective trajectories of depression predict mortality in cancer patients.Journal of behavioral medicine · 2024Article
- Attitudes towards seeking psychological help among community dwelling older adults enrolled in primary care in Chile.BMC geriatrics · 2024Article
- Observational
- The psychological legacy of past obesity and early mortality: evidence from two longitudinal studies.BMC medicine · 2023Article
- The risk of all-cause mortality associated with anxiety: a retrospective cohort study using 'The Health Improvement Network' database.BMC psychiatry · 2023Article
- Depressive symptoms and mortality-findings from Helsinki birth cohort study.Acta psychiatrica Scandinavica · 2023Article
- Association between physical activity and comorbid anxiety/depression in 46 low- and middle-income countries.Journal of affective disorders · 2023Article
- Prevalence and associated factors of anxiety among the population in an urban area of China: a cross-sectional study.BMJ open · 2022Article
- Path Model Factors Associated with Depressive Symptoms among Older Thais Living in Rural Areas.Geriatrics (Basel, Switzerland) · 2022Article
- Effect of healthy lifestyle index and lifestyle patterns on the risk of mortality: A community-based cohort study.Frontiers in medicine · 2022Article
- Comorbid Depressive and Anxiety Symptoms and Their Correlates Among 93,078 Multiethnic Adults in Southwest China.Frontiers in public health · 2021Article
- Chronic Diseases and Associated Factors among Older Adults in Loja, Ecuador.International journal of environmental research and public health · 2020Article
- The association between, depression, anxiety, and mortality in older people across eight low- and middle-income countries: Results from the 10/66 cohort study.International journal of geriatric psychiatry · 2020Article
Corrections and comments
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Authors and funding
14 authors at 9 institutions in 9 countries.
Funding
Abstract
objectivesDepression and anxiety are common mental disorders in later life. Few population-based studies have investigated their potential impacts on mortality in low- and middle-income countries (LMICs). The aim of this study is to examine the associations between depression, anxiety, their comorbidity, and mortality in later life using a population-based cohort study across eight LMICs.
methodsThis analysis was based on the 10/66 cohort study including 15 991 people aged 65 years or above in Cuba, Dominican Republic, Venezuela, Mexico, Peru, Puerto Rico, China, and India, with an average follow-up time of 3.9 years. Subthreshold and clinical levels of depression were determined using EURO-D and ICD-10 criteria, and anxiety was based on Geriatric Mental State (GMS)-Automated Geriatric Examination for Computer Assisted Taxonomy (AGECAT). Cox proportional hazard modelling was used to estimate how having depression, anxiety, or both was associated with mortality adjusting for sociodemographic and health factors.
resultsParticipants with clinical depression (hazard ratio [HR]: 1.45; 95% CI, 1.24-1.70) and subthreshold anxiety (HR: 1.26; 95% CI, 1.15-1.38) had higher risk of mortality than those without the conditions after adjusting for sociodemographic factors and health conditions. Comorbidity of depression and anxiety was associated with a 30% increased risk of mortality but the effect sizes varied across countries (Higgins I
conclusionsDepression and anxiety appear to be associated with mortality in older people living in LMICs. Variation in effect sizes may indicate different barriers to health service access across countries. Future studies may investigate underlying mechanisms and identify potential interventions to reduce the impact of common mental disorders.
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