Evidence map›Paper›PMID 31608437›Full record

Trial reportBritish journal of haematology2020

Retroviral sero-reactivity in LGL leukaemia patients and family members.

Susan B Nyland, David J Feith, Mary Poss, Thomas L Olson, Daniel J Krissinger, Bernard J Poiesz, Francis W Ruscetti, Thomas P Loughran

Open access · bronzeAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in British journal of haematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Susan B NylandDivision of Hematology/Oncology, Department of Medicine, UVA Cancer Center, University of Virginia, Charlottesville, VA, USA.
David J FeithDivision of Hematology/Oncology, Department of Medicine, UVA Cancer Center, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-4981-1691
Mary PossDivision of Hematology/Oncology, Department of Medicine, UVA Cancer Center, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-4147-2410
Thomas L OlsonDivision of Hematology/Oncology, Department of Medicine, UVA Cancer Center, University of Virginia, Charlottesville, VA, USA.
Daniel J KrissingerDepartment of Medicine, Penn State College of Medicine, Hershey, PA, USA.
Bernard J PoieszDivision of Hematology/Oncology, Department of Medicine, State University of New York, Upstate Medical University, Syracuse, NY, USA.
Francis W RuscettiMAR Consulting Inc, Carlsbad, CA, USA.
Thomas P LoughranDivision of Hematology/Oncology, Department of Medicine, UVA Cancer Center, University of Virginia, Charlottesville, VA, USA.
University of Virginia · USPenn State Milton S. Hershey Medical Center · USStructural Analytics (United States) · USSUNY Upstate Medical University · US

Funding

Cancer Research Training Program: From Molecular Mechanisms to Therapeutic StrategiesT32CA009109 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Andrew Carl Dudley, Melanie R Rutkowski · 1985 to 2026
$13.9M
Characterization of the LGL Leukemia Virus (PQ 12)R01CA170334 · NCI · UNIVERSITY OF VIRGINIA · PI LOUGHRAN, THOMAS P., POSS, MARY L. · 2012 to 2015
$1.6M
Bess Family Charitable FundNCI NIH HHS R01 CA170334NCI NIH HHS T32 CA009109
6 · The paper itself

Abstract

T-cell large granular lymphocyte (T-LGL) leukaemia is characterized by a clonal proliferation of cytotoxic T cells and is frequently associated with rheumatoid arthritis. Sera from some LGL leukaemia patients react to a portion of the human T-cell leukaemia virus (HTLV-1/2) transmembrane envelope protein, BA21, although HTLV-1/2 infection is rare in LGL leukaemia patients. Here we show that family members, including spouses, of an LGL leukaemia patient had elevated LGL counts, BA21 reactivity and, additionally, recognition of HIV-1 gp41. Thus, both LGL leukaemia patients and clinically normal contacts sharing the same environment have evidence of exposure to a retrovirus.

Indexed as

HIV-1HIV Envelope Protein gp41Human T-lymphotropic virus 1Human T-lymphotropic virus 2Leukemia, Large Granular LymphocyticT-Lymphocytes, CytotoxicFemaleHumansMaleHIV Envelope Protein gp41epidemiologyleukaemiaretroviruses

Identifiers

PMID31608437
PMCPMC7012702
OpenAlexW2980593917

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.