ArticleEpilepsia2019
Ultra-long-term subcutaneous home monitoring of epilepsy-490 days of EEG from nine patients.
Article in Epilepsia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Automated algorithms for seizure forecast: a systematic review and meta-analysis.Journal of neurology · 2024Pooled it
- Medical Technology: A Systematic Review on Medical Devices Utilized for Epilepsy Prediction and Management.Current neuropharmacology · 2022Pooled it
- A multicenter, video-EEG-based validation of a multimodal wearable device for focal seizure detection in adults: The SeizeIT2 study.Epilepsia open · 2026Trial
- Monitoring Antiseizure Medication Change Using Ultra Long-Term Electroencephalogram: A Multicenter Study.Annals of neurology · 2026Article
- Subdermal Insertable Sensors for Health Monitoring: Applications, Challenges, and Emerging Technologies.Annals of biomedical engineering · 2026Review
- How Much Does the Reduced EEG Montage Matter for Seizure Detection?: A Large-Cohort Simulation Study.medRxiv : the preprint server for health sciences · 2026Article
- Seizure detection using ultra-long-term subcutaneous electroencephalography: A deep learning CNN-BiLSTM approach.Epilepsia · 2026Article
- Unilateral ultra long-term subcutaneous EEG monitoring in drug-refractory idiopathic generalized epilepsy.Epilepsia · 2026Article
- Ultra long-term EEG monitoring for developmental and epileptic encephalopathies: protocol for a prospective study using subscalp EEG.Clinical neurophysiology practice · 2026Article
- Review
- Real-world epilepsy monitoring with ultra-long-term subcutaneous electroencephalography: A 15-month prospective study.Epilepsia · 2025Observational
- The UMPIRE study: A first-in-human multicenter trial of bilateral subscalp monitoring for epileptic seizure detection.Epilepsia · 2025Article
- Article
- Autonomic biosignals, seizure detection, and forecasting.Epilepsia · 2025Review
- Ultra-long-term subcutaneous EEG recordings in ten epilepsy patients: Experiences and circadian rhythms in epileptiform discharges.Epilepsy & behavior reports · 2025Article
- Validation of a discrete electrographic seizure detection algorithm for extended-duration, reduced-channel wearable EEG.Epilepsia · 2025Article
- Real world testing and cost-effectiveness analysis of subcutaneous EEG (REAL-ASE): Protocol for a prospective multicentre interventional trial.Epilepsia open · 2025Article
- Seizure Detection Devices.Journal of clinical medicine · 2025Review
- Improving epilepsy monitoring using long-term, in-home-bi-modal seizure monitoring device: clinical utilities and obstacles from a pilot study.Frontiers in neurology · 2025Article
- Neurostimulation for the Management of Epilepsy: Advances in Targeted Therapy.Current drug targets · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveTo explore the feasibility of home monitoring of epilepsy patients with a novel subcutaneous electroencephalography (EEG) device, including clinical implications, safety, and compliance via the first real-life test.
methodsWe implanted a beta-version of the 24/7 EEG SubQ (UNEEG Medical A/S, Denmark) subcutaneously in nine participants with temporal lobe epilepsy. Data on seizures, adverse events, compliance in using the device, and use of antiepileptic drugs (AEDs) were collected. EEG was recorded for up to 3 months, and all EEG data were reviewed visually to identify electrographic seizures. These were descriptively compared to seizure counts and AED changes reported in diaries from the same period.
resultsFour hundred ninety days of EEG and 338 electrographic seizures were collected. Eight participants completed at least 9 weeks of home monitoring, while one cancelled participation after 4 weeks due to postimplantation soreness. In total, 13 cases of device-related adverse events were registered, none of them serious. Recordings obtained from the device covered 73% of the time, on average (range 45%-91%). Descriptively, electrographic seizure counts were substantially different from diary seizure counts. We uncovered several cases of underreporting and revealed important information on AED response. Electrographic seizure counts revealed circadian distributions of seizures not visible from seizure diaries. SIGNIFICANCE: The study shows that home monitoring for up to 3 months with a subcutaneous EEG device is feasible and well tolerated. No serious adverse device-related events were reported. An objective seizure count can be derived, which often differs substantially from self-reported seizure counts. Larger clinical trials quantifying the benefits of objective seizure counting should be a priority for future research as well as development of algorithms for automated review of data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.