Evidence map›Paper›PMID 31608377›Full record

ArticleThe Journal of clinical endocrinology and metabolism2020

Heritability of Cortisol Production and Metabolism Throughout Adolescence.

Britt J van Keulen, Conor V Dolan, Ruth Andrew, Brian R Walker, Hilleke E Hulshoff Pol, Dorret I Boomsma, Joost Rotteveel, Martijn J J Finken

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. CyberGenomics: Application of Behavioral Genetics in Cybersecurity.Behavioral sciences (Basel, Switzerland) · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Britt J van KeulenEmma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Endocrinology, Amsterdam, The Netherlands.
Conor V DolanDepartment of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands.
Ruth AndrewCentre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK.
Brian R WalkerCentre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, UK.
Hilleke E Hulshoff PolDepartment of Psychiatry, Brian Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Dorret I BoomsmaDepartment of Biological Psychology, Vrije Universiteit Amsterdam, The Netherlands.
Joost RotteveelEmma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Endocrinology, Amsterdam, The Netherlands.
Martijn J J FinkenEmma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Pediatric Endocrinology, Amsterdam, The Netherlands.

Funding

British Heart FoundationWellcome Trust
6 · The paper itself

Abstract

contextInter-individual differences in cortisol production and metabolism emerge with age and may be explained by genetic factors.

objectiveTo estimate the relative contributions of genetic and environmental factors to inter-individual differences in cortisol production and metabolism throughout adolescence.

designProspective follow-up study of twins.

settingNationwide register.

participants218 mono- and dizygotic twins (N = 109 pairs) born between 1995 amd 1996, recruited from the Netherlands Twin Register. Cortisol metabolites were determined in 213, 169, and 160 urine samples at the ages of 9, 12, and 17, respectively.

main outcome measuresThe total contribution of genetic factors (broad-sense heritability) and shared and unshared environmental influences to inter-individual differences in cortisol production and activities of 5α-reductase, 5β-reductase, and 11β-hydroxysteroid dehydrogenases and cytochrome P450 3A4.

resultsFor cortisol production rate at the ages of 9, 12, and 17, broad-sense heritability was estimated as 42%, 30%, and 0%, respectively, and the remainder of the variance was explained by unshared environmental factors. For cortisol metabolism indices, the following heritability was observed: for the A-ring reductases (5α-and 5β-reductases), broad-sense heritability increased with age (to >50%), while for the other indices (renal 11β-HSD2, global 11β-HSD, and CYP3A4), the contribution of genetic factors was highest (68%, 18%, and 67%, respectively) at age 12.

conclusionsThe contribution of genetic factors to inter-individual differences in cortisol production decreased between 12 and 17y, indicative of a predominant role of individual circumstances. For cortisol metabolism, distinct patterns of genetic and environmental influences were observed, with heritability that either increased with age or peaked at age 12y.

Indexed as

11-beta-Hydroxysteroid Dehydrogenases3-Oxo-5-alpha-Steroid 4-DehydrogenaseAdolescentBiosynthetic PathwaysChildCytochrome P-450 CYP3AFemaleFollow-Up StudiesHumansHydrocortisoneHypothalamo-Hypophyseal SystemMaleNetherlandsOxidoreductasesProspective StudiesQuantitative Trait, Heritable11-beta-Hydroxysteroid Dehydrogenases3-Oxo-5-alpha-Steroid 4-Dehydrogenase3-oxo-5 beta-steroid delta 4-dehydrogenaseCytochrome P-450 CYP3AHydrocortisoneOxidoreductases

Identifiers

PMID31608377
PMCPMC7046020

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.