Evidence map›Paper›PMID 31608373›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

The Effect of Community-Based Nutritional Interventions on Children of Women Living With Human Immunodeficiency Virus in Rural India: A 2 × 2 Factorial Intervention Trial.

Sanghyuk S Shin, Veena A Satyanarayana, Maria L Ekstrand, Catherine L Carpenter, Qiao Wang, Kartik Yadav, Padma Ramakrishnan, Suresh Pamujula, Sanjeev Sinha, Adeline M Nyamathi

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In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sanghyuk S ShinSue & Bill Gross School of Nursing, University of California Irvine, Irvine, California, USA.
Veena A SatyanarayanaDepartment of Clinical Psychology, National Institute of Mental Health and Neurosciences, Bengaluru, India.
Maria L EkstrandUniversity of California San Francisco, San Francisco, California, USA.
Catherine L CarpenterDepartment of Epidemiology, University of California Los Angeles, Los Angeles, California, USA.
Qiao WangSue & Bill Gross School of Nursing, University of California Irvine, Irvine, California, USA.
Kartik YadavSue & Bill Gross School of Nursing, University of California Irvine, Irvine, California, USA.
Padma RamakrishnanDepartment of Medicine, All India Institute of Medical Sciences, Delhi, India.
Suresh PamujulaA.C. Subba Reddy Government Medical College, Nellore, India.
Sanjeev SinhaDepartment of Medicine, All India Institute of Medical Sciences, Delhi, India.
Adeline M NyamathiSue & Bill Gross School of Nursing, University of California Irvine, Irvine, California, USA.

Funding

Asha Improving Health and Nutrition of Indian Women with AIDS and Their ChildrenR01MH098728 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EKSTRAND, MARIA L., NYAMATHI, ADELINE M · 2013 to 2017
$2.9M
The Effect of Mixed-strain Mycobacterium tuberculosis Infections on TB Treatment Outcomes in Botswana: A Retrospective Cohort Study.K01AI118559 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SHIN, SANGHYUK SAM · 2015 to 2019
$670k
NIAID NIH HHS K01 AI118559NIMH NIH HHS R01 MH098728
6 · The paper itself

Abstract

backgroundMalnutrition is a common clinical concern among children in low-income communities affected by human immunodeficiency virus (HIV). We examined the effect of a community-based nutritional intervention on anthropometric and clinical outcomes of children of women living with HIV in rural India.

methodsWe assigned women living with HIV and their child (oldest 3-8 years) to 1 of 4 programs: (1) community-based HIV care program, (2) program 1 + nutrition education, (3) program 1 + food supplement, and (4) all elements of programs 1-3. Study data were collected at baseline and months 6, 12, and 18. We applied mixed-effects modeling with restricted maximum likelihood estimation to examine changes in weight (all children) and CD4+ T-cell counts (children with HIV only).

resultsOverall, 600 mother-child pairs were enrolled (150/group) with 100% retention at follow-up visits. Approximately 20% of children were living with HIV. Children in program 4 had higher weight gain than those in programs 1, 2, and 3 at all time points (adjusted P < .001). We found a higher increase in CD4+ T cells across all time points among participants in programs 3 and 4 compared with program 1 (adjusted P < .001). Factorial analysis suggested a synergistic effect of combining nutrition education and food supplements for weight gain but not for increase in CD4+ T cells.

conclusionsA combination of nutrition education and food supplements provided to women living with HIV significantly increased weight and CD4+ T cells, and such interventions can be integrated into HIV-care programs in low-income settings.

Indexed as

HIV InfectionsRural PopulationCD4 Lymphocyte CountChildFemaleHIVHumansIndiaInfantbody weightcommunity interventionlongitudinal follow-upmalnutrition

Identifiers

PMID31608373
PMCPMC7486846

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.