Evidence map›Paper›PMID 31608222›Full record

ArticleFrontiers in oncology2019

HPV DNA Associates With Breast Cancer Malignancy and It Is Transferred to Breast Cancer Stromal Cells by Extracellular Vesicles.

Sabrina De Carolis, Gianluca Storci, Claudio Ceccarelli, Claudia Savini, Lara Gallucci, Pasquale Sansone, Donatella Santini, Renato Seracchioli, Mario Taffurelli, Francesco Fabbri and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Extracellular vesicles in viral disease management.Current research in microbial sciences · 2026
    Review
  6. Discovery of Donor-Derived Exosomal DNA as an Exploratory Biomarker of Kidney Graft Rejection: A Cross-Sectional Study.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. The viral origins of breast cancer.Infectious agents and cancer · 2024
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Sabrina De CarolisDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Gianluca StorciDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Claudio CeccarelliDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Claudia SaviniDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Lara GallucciDepartment of Infectious Diseases, Integrative Virology, CIID, University Hospital Heidelberg, Heidelberg, Germany.
Pasquale SansoneDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Donatella SantiniOperative Unit of Pathology, S. Orsola Malpighi Hospital, Bologna, Italy.
Renato SeracchioliDepartment of Medical & Surgical Sciences, University of Bologna, Bologna, Italy.
Mario TaffurelliDepartment of Medical & Surgical Sciences, University of Bologna, Bologna, Italy.
Francesco FabbriBiosciences Laboratory, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), IRCCS, Meldola, Italy.
Fabrizio RomaniDepartment of Medical Physics, S. Orsola-Malpighi University Hospital, Bologna, Italy.
Gaetano CompagnoneDepartment of Medical Physics, S. Orsola-Malpighi University Hospital, Bologna, Italy.
Cristina GiulianiDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Paolo GaragnaniDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Massimiliano BonafèDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Monica CriccaDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
University of Bologna · ITPoliclinico S.Orsola-Malpighi · ITCornell University · USHeidelberg University · DEIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

A causal link between Human Papillomavirus (HPV) and breast cancer (BC) remains controversial. In spite of this, the observation that HPV DNA is over-represented in the Triple Negative (TN) BC has been reported. Here we remark the high prevalence of HPV DNA (44.4%) in aggressive BC subtypes (TN and HER2+) in a population of 273 Italian women and we convey the presence of HPV DNA in the epithelial and stromal compartments by

Indexed as

circulating HPV DNAextracellular vesicles (EVs)Human Papillomavirus (HPV)stromal cellstriple negative BC

Identifiers

PMID31608222
PMCPMC6756191
OpenAlexW2969885351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.