Evidence map›Paper›PMID 31608069›Full record

ArticleFrontiers in immunology2019

Disruption of Immune Homeostasis in Human Dendritic Cells via Regulation of Autophagy and Apoptosis by

Mohamed M Meghil, Omnia K Tawfik, Mahmoud Elashiry, Mythilypriya Rajendran, Roger M Arce, David J Fulton, Patricia V Schoenlein, Christopher W Cutler

Abstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Review
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  9. Alzheimer's Disease andLife (Basel, Switzerland) · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Blood Leukocyte DNA Methylation Markers of Periodontal Disease and Risk of Lung Cancer in a Case-Control Study Nested in the CLUE II Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024
    Article
  15. Cinnamaldehyde Protects againstInternational journal of molecular sciences · 2024
    Article
  16. Review
  17. Article
  18. Review
  19. Frontiers in oncology · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohamed M MeghilDepartment of Periodontics, Dental College of Georgia at Augusta University, Augusta, GA, United States.
Omnia K TawfikDepartment of Periodontics, Dental College of Georgia at Augusta University, Augusta, GA, United States.
Mahmoud ElashiryDepartment of Periodontics, Dental College of Georgia at Augusta University, Augusta, GA, United States.
Mythilypriya RajendranDepartment of Periodontics, Dental College of Georgia at Augusta University, Augusta, GA, United States.
Roger M ArceDepartment of Periodontics, Dental College of Georgia at Augusta University, Augusta, GA, United States.
David J FultonVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, United States.
Patricia V SchoenleinDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, GA, United States.
Christopher W CutlerDepartment of Periodontics, Dental College of Georgia at Augusta University, Augusta, GA, United States.

Funding

Oral Pathogens and Dendritic Cell SubsetsR01DE014328 · NIDCR · STATE UNIVERSITY NEW YORK STONY BROOK · PI CUTLER, CHRISTOPHER WILLIAM · 2001 to 2014
$5.1M
DC exosome therapy to resolve inflammatory bone loss and oral infectionR01DE029468 · NIDCR · AUGUSTA UNIVERSITY · PI ELSAYED, RANYA · 2021 to 2025
$1.8M
Peripheral blood dendritic cells and periodontitisR21DE020916 · NIDCR · STATE UNIVERSITY NEW YORK STONY BROOK · PI CUTLER, CHRISTOPHER WILLIAM · 2011 to 2012
$362k
NIDCR NIH HHS R01 DE014328NIDCR NIH HHS R01 DE029468NIDCR NIH HHS R21 DE020916
6 · The paper itself

Abstract

As fundamental processes of immune homeostasis, autophagy, and apoptosis must be maintained to mitigate risk of chronic inflammation and autoimmune diseases. Periodontitis is a chronic inflammatory disease characterized by oral microbial dysbiosis, and dysregulation of dendritic cell (DC) and T cell responses. The aim of this study was to elucidate the underlying mechanisms by which the oral microbe

Indexed as

ApoptosisAutophagyPorphyromonas gingivalisBacteroidaceae InfectionsCells, CulturedDendritic CellsFimbriae, BacterialForkhead Box Protein O1HomeostasisHumansProto-Oncogene Proteins c-aktToll-Like Receptor 1Toll-Like Receptor 2Forkhead Box Protein O1FOXO1 protein, humanProto-Oncogene Proteins c-aktTLR1 protein, humanTLR2 protein, humanToll-Like Receptor 1Toll-Like Receptor 2apoptosisautophagy(MeSH) dendritic cellsperiodontitisPorphyromonas gingivalis

Identifiers

PMID31608069
PMCPMC6769118

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.