Evidence map›Paper›PMID 31608062›Full record

ArticleFrontiers in immunology2019

Diverse Immunomodulatory Effects of Individual IFNα Subtypes on Virus-Specific CD8

Julia Dickow, Sandra Francois, Rouven-Luca Kaiserling, Anna Malyshkina, Ingo Drexler, Astrid Maria Westendorf, Karl Sebastian Lang, Mario L Santiago, Ulf Dittmer, Kathrin Sutter

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  8. Article
  9. Characteristics and anatomic location of PD-1Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Article
  11. Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Superior antiviral activity of IFNβ in genital HSV-1 infection.Frontiers in cellular and infection microbiology · 2022
    Article
  13. Article
  14. Article
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Julia DickowInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Sandra FrancoisInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Rouven-Luca KaiserlingInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Anna MalyshkinaInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Ingo DrexlerInstitute of Virology, University Hospital Duesseldorf, Heinrich Heine University Duesseldorf, Düsseldorf, Germany.
Astrid Maria WestendorfInstitute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Karl Sebastian LangInstitute for Immunology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Mario L SantiagoDepartment of Medicine, University of Colorado Denver, Aurora, CO, United States.
Ulf DittmerInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Kathrin SutterInstitute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
University of Duisburg-Essen · DEDüsseldorf University Hospital · DEUniversity of Colorado Denver · US

Funding

Role of Type I IFNs in Mucosal HIV-1 Immunity and PathogenesisR01AI134220 · NIAID · UNIVERSITY OF COLORADO DENVER · PI SANTIAGO, MARIO LUIS, WILSON, CARA C. · 2017 to 2021
$2.7M
NIAID NIH HHS R01 AI134220
6 · The paper itself

Abstract

Clinical administration of Interferon α (IFNα) resulted in limited therapeutic success against some viral infections. Immune modulation of CD8

Indexed as

AnimalsAntiviral AgentsCD8-Positive T-LymphocytesCell ProliferationCell SurvivalCytokinesDendritic CellsHEK293 CellsHumansImmunologic FactorsInterferon-alphaMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutProtein IsoformsVirus ReplicationAntiviral AgentsCytokinesImmunologic FactorsInterferon-alphaProtein Isoformsantigen-specific CD8+ T cell responsescytotoxicityDCsIFNARIFNα subtypes

Identifiers

PMID31608062
PMCPMC6771563
OpenAlexW2971842132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.