Evidence map›Paper›PMID 31607931›Full record

ArticleFrontiers in pharmacology2019

Activation of the Kinin B1 Receptor by Its Agonist Reduces Melanoma Metastasis by Playing a Dual Effect on Tumor Cells and Host Immune Response.

Andrea Gutierrez Maria, Patrícia Dillemburg-Pilla, Marina de Toledo Durand, Elaine Medeiros Floriano, Adriana Oliveira Manfiolli, Simone Gusmão Ramos, João Bosco Pesquero, Clara Nahmias, Claudio M Costa-Neto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Andrea Gutierrez MariaDepartment of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Patrícia Dillemburg-PillaDepartment of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Marina de Toledo DurandDepartment of Medicine, University of Ribeirão Preto, Ribeirão Preto, Brazil.
Elaine Medeiros FlorianoDepartment of Pathology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Adriana Oliveira ManfiolliDepartment of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Simone Gusmão RamosDepartment of Pathology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
João Bosco PesqueroDepartment of Biophysics, Federal University of São Paulo, São Paulo, Brazil.
Clara NahmiasINSERM U981, Department of Molecular Medicine, Gustave Roussy Cancer Center, Villejuif, France.
Claudio M Costa-NetoDepartment of Biochemistry and Immunology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.
Universidade de São Paulo · BRInstitut Gustave Roussy · FRUniversidade de Ribeirão Preto · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastatic melanoma is an aggressive type of skin cancer leading half of the patients to death within 8-10 months after diagnosis. Kinins are peptides that interact with B1 and B2 receptors playing diverse biological roles. We investigated whether treatment with B1 receptor agonist, des-Arg

Indexed as

B1 receptordes-Arg9-bradykininimmune responseinflammationmelanomametastasistumor microenvironment

Identifiers

PMID31607931
PMCPMC6774293
OpenAlexW2970047229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.