ReviewFrontiers in cellular neuroscience2019
Post Stroke Seizures and Epilepsy: From Proteases to Maladaptive Plasticity.
Review in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Role of Genetics in Stroke Risk and Outcome: A Review of Current Evidence.Brain and behavior · 2025Pooled it
- Neuronal substrates of motor impairment after subcortical ischemic stroke: a functional neuroimaging meta-analysis.Brain structure & function · 2025Pooled it
- Risk factors of post-stroke epilepsy among pediatric population: a systematic review.Frontiers in neurology · 2025Pooled it
- Incidence and predictors of early post-stroke seizures among adult stroke patients at University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia: a retrospective cohort study.BMC research notes · 2026Article
- Association of deep vein thrombosis with poststroke epilepsy after acute ischemic stroke: a multicenter retrospective cohort study.Frontiers in neurology · 2026Article
- Electroencephalography in stroke Care: From acute monitoring to Post-Stroke epilepsy.Clinical neurophysiology practice · 2026Review
- Criticality and increased intrinsic neural timescales in stroke.NPJ systems biology and applications · 2025Article
- Dendritic beading during early brain development impairs signal transmission and synaptic plasticity.Acta neuropathologica communications · 2025Article
- Probiotics and the Gut-Brain Axis: Emerging Therapeutic Strategies for Epilepsy and Depression Comorbidity.Foods (Basel, Switzerland) · 2025Review
- Clinical Features and Prognostic Analysis of Elderly Patients With Late-Onset Epilepsy.Brain and behavior · 2025Article
- Risk factors of posthemorrhagic seizure in spontaneous intracerebral hemorrhage.Neurosurgical review · 2025Article
- Therapeutic and preventive strategies based on the maladaptive plasticity hypothesis for Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- Repetitive transcranial magnetic stimulation for post-stroke epilepsy: a mini-review.Acta epileptologica · 2024Review
- Long-Term Safety and Efficacy of Lacosamide Combined with NOACs in Post-Stroke Epilepsy and Atrial Fibrillation: A Prospective Longitudinal Study.Journal of personalized medicine · 2024Article
- Coherent activity within and between hemispheres: cortico-cortical connectivity revealed by rTMS of the right posterior parietal cortex.Frontiers in human neuroscience · 2024Article
- The immunomodulatory mechanism of acupuncture treatment for ischemic stroke: research progress, prospects, and future direction.Frontiers in immunology · 2024Review
- Article
- Evaluation of fMRI activation in post-stroke patients with movement disorders after repetitive transcranial magnetic stimulation: a scoping review.Frontiers in neurology · 2023Article
- LTBP1 Gene Expression in the Cerebral Cortex and its Neuroprotective Mechanism in Mice with Postischemic Stroke Epilepsy.Current pharmaceutical biotechnology · 2023Article
- Early seizures in stroke - frequency, risk factors, and effect on patient outcomes in a tertiary center in Saudi Arabia.Neurosciences (Riyadh, Saudi Arabia) · 2022Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post stroke epilepsy (PSE) is the most common cause of seizures in the elderly, yet its underlying mechanism is poorly understood. The classification of PSE is confusing, and there is neither a clear agreement on its incidence and prognosis nor a consensus about specific treatments. The diagnosis of PSE requires the occurrence of late seizures: epileptic events occurring 1 week or more after an ischemic stroke. Late seizures differ from early seizures by the presence of permanent structural changes in the brain. Those structural changes cause a shift in the regulation of neuronal firing and lead to circuit dysfunctions, and thus to a long-term epileptic condition. The coagulation cascade and some of its major components, serine proteases such as thrombin, are known to participate in the acute phase of a stroke. Recent discoveries found that thrombin and its protease-activated receptor 1 (PAR1), are involved in the development of maladaptive plasticity. Therefore, we suggest that thrombin and PAR1 may have a role in the development of PSE by inducing permanent structural changes after the ischemic events toward the development of epileptic focuses. We are confident that future studies will lead to a better understanding of the pathophysiology of PSE, as well as development of more directed therapies for its treatment.
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