Evidence map›Paper›PMID 31607850›Full record

ArticleFrontiers in neuroscience2019

Inflammation Induced Sensory Nerve Growth and Pain Hypersensitivity Requires the N-Type Calcium Channel Cav2.2.

Saumitra Pitake, Leah J Middleton, Ishmail Abdus-Saboor, Santosh K Mishra

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Channels (Austin, Tex.) · 2026
    Article
  3. Article
  4. Noradrenergic αMolecular neurobiology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Regulatory Action of Calcium and Calcium Channels in Pain Pathways.International journal of biological sciences · 2025
    Review
  9. Article
  10. Article
  11. Peripheral CaeNeuro · 2024
    Article
  12. Peripheral CabioRxiv : the preprint server for biology · 2024
    Article
  13. Review
  14. Interleukin-1α links peripheral CaScientific reports · 2024
    Article
  15. Interleukin-1α links peripheral CabioRxiv : the preprint server for biology · 2024
    Article
  16. Review
  17. A peptidomimetic modulator of the CaProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Saumitra PitakeDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States.
Leah J MiddletonDepartment of Biology, University of Pennsylvania, Philadelphia, PA, United States.
Ishmail Abdus-SaboorDepartment of Biology, University of Pennsylvania, Philadelphia, PA, United States.
Santosh K MishraDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States.
University of Pennsylvania · USNorth Carolina State University · US

Funding

Determining the functions of molecularly defined populations of nociceptors in spinal and dental painR00DE026807 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI ABDUS-SABOOR, ISHMAIL JOHN · 2018 to 2020
$904k
Determining the functions of molecularly defined populations of nociceptors in spinal and dental painK99DE026807 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI ABDUS-SABOOR, ISHMAIL JOHN · 2017 to 2017
$103k
NIDCR NIH HHS K99 DE026807NIDCR NIH HHS R00 DE026807
6 · The paper itself

Abstract

Voltage-gated calcium channels (VGCCs) are important mediators of pain hypersensitivity during inflammatory states, but their role in sensory nerve growth remains underexplored. Here, we assess the role of the N-type calcium channel Cav2.2 in the complete Freund's adjuvant (CFA) model of inflammatory pain. We demonstrate with

Indexed as

Cav2.2hyperalgesiainflammationnerve growthpain

Identifiers

PMID31607850
PMCPMC6761232
OpenAlexW2971824552

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.