ArticleDevelopmental cell2019
Planar Differential Growth Rates Initiate Precise Fold Positions in Complex Epithelia.
Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Article
- Growth-rate coordination across the width of a leaf preserves its flatness.PLoS biology · 2026Article
- Mechanics of compression-driven morphogenesis.Development (Cambridge, England) · 2026Review
- Robinow syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease model.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Novel tissue mechanics-guided cellular flows drive the formation of feather follicles.The EMBO journal · 2026Article
- Cilia-driven epithelial folding and unfolding in an early diverging animal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mechanobiological engineering strategies for organoid culture.APL bioengineering · 2025Review
- A multi-tiered mechanical mechanism shapes the early neural plate.Nature communications · 2025Article
- Reciprocal folding dynamics in cellular networks at the stroma-basement membrane interface.Acta biomaterialia · 2025Article
- The Mechanics of Building Functional Organs.Cold Spring Harbor perspectives in biology · 2025Review
- Tumor Cell Plasticity and Stromal Microenvironment Distinguish Papillary and Follicular Growth Patterns in a Mouse Model of BRAFV600E-Induced Thyroid Cancer.Cancer research communications · 2025Article
- Cell recruitment and the origins of Anterior-Posterior asymmetries in the Drosophila wing.PloS one · 2025Article
- Mechanical state transitions in the regulation of tissue form and function.Nature reviews. Molecular cell biology · 2024Review
- Cell proliferation and Notch signaling coordinate the formation of epithelial folds in the Drosophila leg.Development (Cambridge, England) · 2024Article
- Balancing competing effects of tissue growth and cytoskeletal regulation during Drosophila wing disc development.Nature communications · 2024Article
- Compressive stress gradients direct mechanoregulation of anisotropic growth in the zebrafish jaw joint.PLoS computational biology · 2024Article
- Ionizing radiation induces cells with past caspase activity that contribute to the adult organ in Drosophila and show reduced Loss of Heterozygosity.Cell death discovery · 2024Article
- Modeling the extracellular matrix in cell migration and morphogenesis: a guide for the curious biologist.Frontiers in cell and developmental biology · 2024Review
- Forceful patterning: theoretical principles of mechanochemical pattern formation.EMBO reports · 2023Review
- Sculpting with stiffness: rigidity as a regulator of morphogenesis.Biochemical Society transactions · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Tissue folding is a fundamental process that shapes epithelia into complex 3D organs. The initial positioning of folds is the foundation for the emergence of correct tissue morphology. Mechanisms forming individual folds have been studied, but the precise positioning of folds in complex, multi-folded epithelia is less well-understood. We present a computational model of morphogenesis, encompassing local differential growth and tissue mechanics, to investigate tissue fold positioning. We use the Drosophila wing disc as our model system and show that there is spatial-temporal heterogeneity in its planar growth rates. This differential growth, especially at the early stages of development, is the main driver for fold positioning. Increased apical layer stiffness and confinement by the basement membrane drive fold formation but influence positioning to a lesser degree. The model successfully predicts the in vivo morphology of overgrowth clones and wingless mutants via perturbations solely on planar differential growth in silico.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.