ArticleDevelopmental cell2019
Characterization of Button Loci that Promote Homologous Chromosome Pairing and Cell-Type-Specific Interchromosomal Gene Regulation.
Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 63 citations in OpenAlex.
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- Chromatin insulators homie and nhomie can interact with distant copies either together or separately, with distinct outcomes for enhancer-promoter interactions.PLoS genetics · 2026Article
- FISH-Dist: An Automated Pipeline for 3D Genomic Spatial Distance Quantification in FISH Imaging.Bioengineering (Basel, Switzerland) · 2026Article
- The functional organization of chromosome territories in single nuclei during zygotic genome activation.Scientific reports · 2026Article
- Non-homologous sequence interactions during meiosis: meiotic challenges and evolutionary opportunities.Current opinion in genetics & development · 2025Review
- The homie insulator has sub-elements with different insulating and long-range pairing properties.Genetics · 2025Article
- The functional organization of chromosome territories in single nuclei during zygotic genome activation.bioRxiv : the preprint server for biology · 2025Article
- ThebioRxiv : the preprint server for biology · 2025Article
- Drosophila ring chromosomes interact with sisters and homologs to produce anaphase bridges in mitosis.Genetics · 2024Article
- Drosophila ring chromosomes interact with sisters and homologs to produce anaphase bridges in mitosis.bioRxiv : the preprint server for biology · 2024Article
- The zinc-finger protein Z4 cooperates with condensin II to regulate somatic chromosome pairing and 3D chromatin organization.Nucleic acids research · 2024Article
- Heterochromatic 3D genome organization is directed by HP1a- and H3K9-dependent and independent mechanisms.Molecular cell · 2024Article
- Building Haplotype-Resolved 3D Genome Maps of Chicken Skeletal Muscle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Modeling homologous chromosome recognition via nonspecific interactions.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Transcriptional priming and chromatin regulation during stochastic cell fate specification.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Uncharted territories: Solving the mysteries of male meiosis in flies.PLoS genetics · 2024Review
- Transvection between nonallelic genomic positions in Drosophila.G3 (Bethesda, Md.) · 2024Article
- The activity of engrailed imaginal disc enhancers is modulated epigenetically by chromatin and autoregulation.PLoS genetics · 2023Article
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14 authors at 2 institutions in 2 countries.
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Abstract
Homologous chromosomes colocalize to regulate gene expression in processes including genomic imprinting, X-inactivation, and transvection. In Drosophila, homologous chromosomes pair throughout development, promoting transvection. The "button" model of pairing proposes that specific regions along chromosomes pair with high affinity. Here, we identify buttons interspersed across the fly genome that pair with their homologous sequences, even when relocated to multiple positions in the genome. A majority of transgenes that span a full topologically associating domain (TAD) function as buttons, but not all buttons contain TADs. Additionally, buttons are enriched for insulator protein clusters. Fragments of buttons do not pair, suggesting that combinations of elements within a button are required for pairing. Pairing is necessary but not sufficient for transvection. Additionally, pairing and transvection are stronger in some cell types than in others, suggesting that pairing strength regulates transvection efficiency between cell types. Thus, buttons pair homologous chromosomes to facilitate cell-type-specific interchromosomal gene regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.