Evidence map›Paper›PMID 31607542›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2020

Interplay between Triadin and Calsequestrin in the Pathogenesis of CPVT in the Mouse.

Marine Cacheux, Jérémy Fauconnier, Jérôme Thireau, Alexis Osseni, Jacques Brocard, Nathalie Roux-Buisson, Julie Brocard, Julien Fauré, Alain Lacampagne, Isabelle Marty

Open access · hybridAbstract read
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Molecular Pathways and Animal Models of Arrhythmias.Advances in experimental medicine and biology · 2024
    Article
  5. Article
  6. Article
  7. How does flecainide impact RyR2 channel function?The Journal of general physiology · 2022
    Article
  8. Calsequestrin, a key protein in striated muscle health and disease.Journal of muscle research and cell motility · 2021
    Review
  9. Mechanisms underlying pathological CaPflugers Archiv : European journal of physiology · 2021
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Marine CacheuxGrenoble Institut Neurosciences, INSERM, Grenoble Alpes University, U1216, CHU Grenoble Alpes, 38700 La Tronche, France.
Jérémy FauconnierUniversity of Montpellier, INSERM U1046, CNRS 9214, CHU Montpellier, 34295 Montpellier, France.
Jérôme ThireauUniversity of Montpellier, INSERM U1046, CNRS 9214, CHU Montpellier, 34295 Montpellier, France.
Alexis OsseniGrenoble Institut Neurosciences, INSERM, Grenoble Alpes University, U1216, CHU Grenoble Alpes, 38700 La Tronche, France.
Jacques BrocardGrenoble Institut Neurosciences, INSERM, Grenoble Alpes University, U1216, CHU Grenoble Alpes, 38700 La Tronche, France.
Nathalie Roux-BuissonGrenoble Institut Neurosciences, INSERM, Grenoble Alpes University, U1216, CHU Grenoble Alpes, 38700 La Tronche, France.
Julie BrocardGrenoble Institut Neurosciences, INSERM, Grenoble Alpes University, U1216, CHU Grenoble Alpes, 38700 La Tronche, France.
Julien FauréGrenoble Institut Neurosciences, INSERM, Grenoble Alpes University, U1216, CHU Grenoble Alpes, 38700 La Tronche, France.
Alain LacampagneUniversity of Montpellier, INSERM U1046, CNRS 9214, CHU Montpellier, 34295 Montpellier, France. Electronic address: alain.lacampagne@inserm.fr.
Isabelle MartyGrenoble Institut Neurosciences, INSERM, Grenoble Alpes University, U1216, CHU Grenoble Alpes, 38700 La Tronche, France. Electronic address: isabelle.marty@univ-grenoble-alpes.fr.
Inserm · FRCentre National de la Recherche Scientifique · FRGrenoble Institute of Neurosciences · FRPhysiologie et Médecine Expérimentale du Coeur et des Muscles · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recessive forms of catecholaminergic polymorphic ventricular tachycardia (CPVT) are induced by mutations in genes encoding triadin or calsequestrin, two proteins that belong to the Ca

Indexed as

AlkaloidsAnimalsArrhythmias, CardiacCalciumCalcium SignalingCalsequestrinDependovirusDisease Models, AnimalGenetic TherapyHEK293 CellsHumansIntracellular Signaling Peptides and ProteinsMaleMiceMice, KnockoutMuscle ProteinsAlkaloidsCalciumCalsequestrinCASQ2 protein, humancasq2 protein, mouseIntracellular Signaling Peptides and ProteinskifunensineMuscle ProteinsTrdn protein, mouseTrdn protein, ratCa(2+) releasecardiac arrhythmiagene therapygenetic diseasesarcoplasmic reticulum

Identifiers

PMID31607542
PMCPMC6952166
OpenAlexW2972635844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.