Evidence map›Paper›PMID 31607123›Full record

ArticleBiochemistry2019

Defects in the Assembly of Ribosomes Selected for β-Amino Acid Incorporation.

Fred R Ward, Zoe L Watson, Omer Ad, Alanna Schepartz, Jamie H D Cate

Abstract read
In one paragraph

Article in Biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. RNA language models predict mutations that improve RNA function.bioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Topological crossing in the misfoldedProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fred R WardDepartment of Molecular and Cell Biology , University of California-Berkeley , Berkeley , California 94720 , United States.
Zoe L WatsonDepartment of Chemistry , University of California-Berkeley , Berkeley , California 94720 , United States.
Omer AdDepartment of Chemistry , Yale University , New Haven , Connecticut 06520 , United States.
Alanna SchepartzDepartment of Molecular and Cell Biology , University of California-Berkeley , Berkeley , California 94720 , United States.ORCID 0000-0003-2127-3932
Jamie H D CateDepartment of Molecular and Cell Biology , University of California-Berkeley , Berkeley , California 94720 , United States.ORCID 0000-0001-5965-7902

Funding

TUBULIN STRUCTURE BY ELECTRON CRYSTALLOGRAPHYP01GM051487 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI DOUDNA, JENNIFER A · 1994 to 2018
$27.6M
Repurposing the Ribosome for Exotic PolymersR01GM114454 · NIGMS · YALE UNIVERSITY · PI SCHEPARTZ, ALANNA · 2017 to 2019
$1.1M
NIGMS NIH HHS P01 GM051487NIGMS NIH HHS R01 GM114454
6 · The paper itself

Abstract

Ribosome engineering has emerged as a promising field in synthetic biology, particularly concerning the production of new sequence-defined polymers. Mutant ribosomes have been developed that improve the incorporation of several nonstandard monomers including d-amino acids, dipeptides, and β-amino acids into polypeptide chains. However, there remains little mechanistic understanding of how these ribosomes catalyze incorporation of these new substrates. Here, we probed the properties of a mutant ribosome-P7A7-evolved for better

Indexed as

Amino AcidsEscherichia coliModels, MolecularMutationPeptidesProtein BiosynthesisRibosomesAmino AcidsPeptides

Identifiers

PMID31607123
PMCPMC8435211

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.