ArticleNeurospine2019
The Clinical Implications and Complications of Anterior Versus Posterior Surgery for Multilevel Cervical Ossification of the Posterior Longitudinal Ligament; An Updated Systematic Review and Meta-Analysis.
Article in Neurospine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Efficacy and safety of Vertebral Body Sliding Osteotomy (VBSO) versus Anterior Cervical Corpectomy and Fusion (ACCF): A systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Pooled it
- Clinical efficacy and complications of 10 surgical interventions for cervical ossification of the posterior longitudinal ligament: an updated systematic review and network meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Accuracy and precision of the spinal instability neoplastic score (SINS) for predicting vertebral compression fractures after radiotherapy in spinal metastases: a meta-analysis.Scientific reports · 2021Pooled it
- Integrated miRNA-mRNA network revealing the key molecular characteristics of ossification of the posterior longitudinal ligament.Medicine · 2020Pooled it
- Machine-learning-based models for the optimization of post-cervical spinal laminoplasty outpatient follow-up schedules.BMC medical informatics and decision making · 2024Trial
- Anterior versus Posterior Fusion Surgery for Cervical Ossification of the Posterior Longitudinal Ligament: A Systematic Review and Meta-Analysis.Spine surgery and related research · 2026Article
- Clinical Outcomes Following Cervical Fusion in Patients with Dialysis-Related Spondyloarthropathy: A Systematic Review.Spine surgery and related research · 2026Review
- Quantitative evaluation of cervical muscles in patients with degenerative cervical myelopathy using diffusion tensor imaging metrics.Bone & joint research · 2026Article
- Angiogenesis in ossification of the posterior longitudinal ligament: progress from mechanism to targeted intervention.Frontiers in cell and developmental biology · 2026Review
- Anterior cervical decompression improves medial plantar pressure in OPLL with gait disturbance: a 24-month retrospective cohort study.European journal of medical research · 2025Article
- Article
- Deep learning for identifying cervical ossification of the posterior longitudinal ligament: a systematic review and meta-analysis.Quantitative imaging in medicine and surgery · 2025Article
- Surgical Management of Cervical Ossification of Posterior Longitudinal Ligament: The Treatment Algorithm and Outcome.Cureus · 2023Article
- What Is the Impact of Surgical Approach in the Treatment of Degenerative Cervical Myelopathy in Patients With OPLL? A Propensity-Score Matched, Multi-Center Analysis on Inpatient and Post-Discharge 90-Day Outcomes.Global spine journal · 2023Article
- Cervical kinematic change after posterior full-endoscopic cervical foraminotomy for disc herniation or foraminal stenosis.PloS one · 2023Article
- A Comparison of Various Surgical Treatments for Degenerative Cervical Myelopathy: A Propensity Score Matched Analysis.Global spine journal · 2022Article
- Perioperative Complications of Anterior Decompression with Fusion in Degenerative Cervical Myelopathy-A Comparative Study between Ossification of Posterior Longitudinal Ligament and Cervical Spondylotic Myelopathy Using a Nationwide Inpatient Database.Journal of clinical medicine · 2022Article
- Radiological Changes in Adjacent and Index Levels after Cervical Disc Arthroplasty.Yonsei medical journal · 2022Article
- Preoperative Radiological Parameters to Predict Clinical and Radiological Outcomes after Laminoplasty.Journal of Korean Neurosurgical Society · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveTheoretically, the optimal approach is determined by the status of ossification of the posterior longitudinal ligament (OPLL) and sagittal alignment. However, there have long been disputes about the optimum surgical approach of OPLL. This study is to compare risk-effectiveness between anterior decompression and fusion (ADF) and laminoplasty and laminectomy with fusion (LP/LF) for the patient with cervical myelopathy due to multilevel cervical OPLL.
methodsWe searched core databases, and compared complication and outcomes between ADF and LP/LF for patients with multiple OPLL for the cervical spine. The incidence of complications such as neurologic deterioration, C5 palsy, and dura tear was assessed. Changes in JOA score between baseline and final evaluations were assessed for 2 groups. The minimal clinically important difference (MCID) was utilized for evaluating clinical significance. We calculated Peto odds ratio (POR) and mean difference for the incidence and continuous variables, respectively.
resultsWe included data from 21 articles involving 3,872 patients with cervical myelopathy with OPLL. Major neurologic deficits such as paraplegia, quadriplegia developed 2.17% in the ADF group and 1.11% in the LP/LF group, and POR was 2.16. Mean difference of JOA score improvement of 2 groups was 1.30, and the mean difference showed a statistical significance. However, 1.3 points of JOA improvement cannot reach 2.5 points of the MCID.
conclusionAnterior surgery often led to rare but critical complications, and the difference of neurological improvement between 2 groups was below a clinically meaningful level. Posterior surgeries may be appropriate in the treatment of multilevel cervical myelopathy with OPLL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.