Evidence map›Paper›PMID 31606969›Full record

ArticleCell journal2020

met1 DNA Methyltransferase Controls TERT Gene Expression: A New Insight to The Role of Telomerase in Development.

Maryam Zangi, Mohammad Bagher Bagherieh Najjar, Masoud Golalipour, Mahnaz Aghdasi

Open access · greenAbstract read
In one paragraph

Article in Cell journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Maryam ZangiDepartment of Biology, Faculty of Science, Golestan University, Gorgan, Iran.
Mohammad Bagher Bagherieh NajjarDepartment of Biology, Faculty of Science, Golestan University, Gorgan, Iran.
Masoud GolalipourCellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Electronic Address: gapmasood@goums.ac.ir.
Mahnaz AghdasiDepartment of Biology, Faculty of Science, Golestan University, Gorgan, Iran.
Golestan University · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDNA methylation systems are essential for proper embryo development. Methylation defects lead to developmental abnormalities. Furthermore, changes in telomerase gene expression can affect stability of chromosomes and produces abnormal growth. Therefore, defects in both methylation and telomerase gene expression can lead to developmental abnormalities. We hypothesized that mutation in the methylation systems may induce developmental abnormalities through changing telomerase gene expression. MATERIALS AND

methodsIn this experimental study, we used

resultsTelomerase gene expression level in homozygous

conclusionOur results suggested that

Indexed as

Developmental Abnormalitiesmet1Telomerase

Identifiers

PMID31606969
PMCPMC6791074
OpenAlexW2984758843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.