Evidence map›Paper›PMID 31606858›Full record

ArticleAging clinical and experimental research2021

Familial Alzheimer's disease presenilin-2 mutants affect Ca

Diana Pendin, Cristina Fasolato, Emy Basso, Riccardo Filadi, Elisa Greotti, Luisa Galla, Chiara Gomiero, Alessandro Leparulo, Nelly Redolfi, Elena Scremin and 3 more

Abstract read
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In one paragraph

Article in Aging clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases.International journal of molecular sciences · 2020
    Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Diana Pendin *Neuroscience Institute - Italian National Research Council (CNR), Padua, Italy.
Cristina Fasolato *Department of Biomedical Sciences, University of Padua, Padua, Italy.
Emy BassoNeuroscience Institute - Italian National Research Council (CNR), Padua, Italy.
Riccardo FiladiNeuroscience Institute - Italian National Research Council (CNR), Padua, Italy.
Elisa GreottiNeuroscience Institute - Italian National Research Council (CNR), Padua, Italy.
Luisa GallaNeuroscience Institute - Italian National Research Council (CNR), Padua, Italy.
Chiara GomieroNeuroscience Institute - Italian National Research Council (CNR), Padua, Italy.
Alessandro LeparuloDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Nelly RedolfiDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Elena ScreminDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Nicola VajenteDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Tullio PozzanNeuroscience Institute - Italian National Research Council (CNR), Padua, Italy. tullio.pozzan@unipd.it.
Paola PizzoNeuroscience Institute - Italian National Research Council (CNR), Padua, Italy.
University of Padua · ITNational Research Council · ITNeuroscience Institute · IT

Funding

Consiglio Nazionale delle Ricerche Aging project
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most frequent cause of dementia in the elderly. Few cases are familial (FAD), due to autosomal dominant mutations in presenilin-1 (PS1), presenilin-2 (PS2) or amyloid precursor protein (APP). The three proteins are involved in the generation of amyloid-beta (Aβ) peptides, providing genetic support to the hypothesis of Aβ pathogenicity. However, clinical trials focused on the Aβ pathway failed in their attempt to modify disease progression, suggesting the existence of additional pathogenic mechanisms. Ca

Indexed as

Alzheimer DiseaseAgedAmyloid beta-PeptidesBrainHomeostasisHumansPresenilin-1Presenilin-2Amyloid beta-PeptidesPresenilin-1Presenilin-2Alzheimer’s diseaseAmyloid-betaBrain networkCa2+ probesCalcium homeostasisPresenilin

Identifiers

PMID31606858
OpenAlexW2979346464

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.