Evidence map›Paper›PMID 31606831›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2020

Comparison of

Chih-Hua Yeh, Sheng-Chieh Chan, Chien-Yu Lin, Tzu-Chen Yen, Joseph Tung-Chieh Chang, Sheung-Fat Ko, Kang-Hsing Fan, Hung-Ming Wang, Chun-Ta Liao, Shu-Hang Ng

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In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. The Diagnostic and Prognostic Value ofDiagnostics (Basel, Switzerland) · 2025
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  10. Diagnosis and staging of cardiac masses: additional value of CMR withEuropean journal of nuclear medicine and molecular imaging · 2022
    Article
  11. Diagnostic Accuracy ofContrast media & molecular imaging · 2022
    Observational
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chih-Hua YehDepartment of Medical Imaging and Intervention, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Sheng-Chieh ChanDepartment of Nuclear Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Chien-Yu LinDepartment of Radiation Oncology, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Tzu-Chen YenMolecular Imaging Center, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Joseph Tung-Chieh ChangDepartment of Radiation Oncology, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Sheung-Fat KoDepartment of Medical Imaging and Intervention, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Kang-Hsing FanDepartment of Radiation Oncology, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Hung-Ming WangDivision of Medical Oncology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Chun-Ta LiaoDepartment of Otorhinolaryngology, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan.
Shu-Hang NgDepartment of Medical Imaging and Intervention, Linkou Chang Gung Memorial Hospital and Chang Gung University, Taoyuan, Taiwan. shuhangng@gmail.com.ORCID 0000-0002-1842-6179

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn this prospective study, we sought to compare the clinical utility of fluorodeoxyglucose PET/MRI, MRI, and PET/CT in the detection of synchronous cancers and distant metastases in patients with oropharyngeal and hypopharyngeal squamous cell carcinoma (OHSCC).

methodsWe examined 198 consecutive patients with biopsy-proven OHSCC who agreed to receive chemoradiation. All patients underwent pretreatment PET/MRI and PET/CT on the same day. Patients were followed-up for a minimum of 12 months or until death. The McNemar's test and receiver-operating characteristic (ROC) curves were used to compare sensitivity/specificity and the diagnostic capabilities of PET/MRI, MRI, and PET/CT, respectively.

resultsWe identified 55 patients (27.7%) who had synchronous cancers and/or distant metastases (number of involved sites: 83). The results of site-based analysis revealed that the sensitivity of PET/MRI was 15.7% higher than that of MRI (73.5% versus 57.8%, p < 0.001) and 3.6% higher compared with PET/CT (73.5% versus 69.9%, p = 0.083), whereas the sensitivity of PET/CT was 12.1% higher than that of MRI (69.9% versus 57.8%, p = 0.012). On a patient-basis, ROC curve analysis demonstrated that PET/MRI yielded a greater area under curve than MRI (0.930 versus 0.905, p = 0.023). There were no significant differences in terms of diagnostic capability between MRI and PET/CT (0.905 versus 0.917, p = 0.469) and between PET/MRI and PET/CT (0.930 versus 0.917, p = 0.062).

conclusionsIn our cohort, PET/MRI showed a significantly higher diagnostic capability than MRI and no significant difference compared with PET/CT for the detection of synchronous cancers or distant metastases in patients with OHSCC.

Indexed as

Fluorodeoxyglucose F18Head and Neck NeoplasmsHumansMagnetic Resonance ImagingPositron-Emission TomographyPositron Emission Tomography Computed TomographyProspective StudiesRadiopharmaceuticalsSensitivity and SpecificitySquamous Cell Carcinoma of Head and NeckFluorodeoxyglucose F18RadiopharmaceuticalsDistant metastasesHypopharyngeal squamous cell carcinomaMRIOropharyngeal squamous cell carcinomaPET/CTPET/MRISynchronous cancer

Identifiers

PMID31606831

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.