Evidence map›Paper›PMID 31606798›Full record

ArticleJournal of materials science. Materials in medicine2019

Osseointegration effects of local release of strontium ranelate from implant surfaces in rats.

Ali Alenezi, Silvia Galli, Saba Atefyekta, Martin Andersson, Ann Wennerberg

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Anodic TiONanomaterials (Basel, Switzerland) · 2021
    Review
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  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Ali AleneziDepartment of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden. ali.alenezi@mau.se.ORCID http://orcid.org/0000-0001-6929-974X
Silvia GalliDepartment of Prosthodontics, Faculty of Odontology, Malmö University, Malmö, Sweden.
Saba AtefyektaDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, Göteborg, Sweden.
Martin AnderssonDepartment of Chemistry and Chemical Engineering, Chalmers University of Technology, Göteborg, Sweden.
Ann WennerbergDepartment of Prosthodontics/Dental Materials Science, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
Chalmers University of Technology · SEMalmö University · SEQassim University · SAUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNumerous studies have reported the beneficial effects of strontium on bone growth, particularly by stimulating osteoblast proliferation and differentiation. Thus, strontium release around implants has been suggested as one possible strategy to enhance implant osseointegration.

aimThis study aimed to evaluate whether the local release of strontium ranelate (Sr-ranelate) from implants coated with mesoporous titania could improve bone formation around implants in an animal model. MATERIALS AND

methodsMesoporous titania (MT) thin coatings were formed utilizing the evaporation induced self-assembly (EISA) method using Pluronic (P123) with or without the addition of poly propylene glycol (PPG) to create materials with two different pore sizes. The MT was deposited on disks and mini-screws, both made of cp Ti grade IV. Scanning electron microscopy (SEM) was performed to characterize the MT using a Leo Ultra55 FEG instrument (Zeiss, Oberkochen, Germany). The MT was loaded with Sr-ranelate using soaking and the drug uptake and release kinetics to and from the surfaces were evaluated using quartz crystal microbalance with dissipation monitoring (QCM-D) utilizing a Q-sense E4 instrument. For the in vivo experiment, 24 adult rats were analyzed at two time points of implant healing (2 and 6 weeks). Titanium implants shaped as mini screws were coated with MT films and divided into two groups; supplied with Sr-ranelate (test group) and without Sr-ranelate (control group). Four implants (both test and control) were inserted in the tibia of each rat. The in vivo study was evaluated using histomorphometric analyses of the implant/bone interphase using optical microscopy.

resultsSEM images showed the successful formation of evenly distributed MT films covering the entire surface with pore sizes of 6 and 7.2 nm, respectively. The QCM-D analysis revealed an absorption of 3300 ng/cm

conclusionThis study could not confirm any positive effects of Sr-ranelate on implant osseointegration.

Indexed as

Dental ProsthesisDental Prosthesis DesignAnimalsBone and BonesCell DifferentiationCell ProliferationCoated Materials, BiocompatibleDental ImplantsDrug Delivery SystemsFemaleFemurMaterials TestingMicroscopy, Electron, ScanningOsseointegrationOsteogenesisRatsCoated Materials, BiocompatibleDental ImplantsStrontiumstrontium ranelateThiophenesTitanium

Identifiers

PMID31606798
PMCPMC6790188
OpenAlexW2980259099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.