ArticleJournal of cancer research and clinical oncology2020
The age-adjusted Charlson comorbidity index as a predictor of overall survival of surgically treated non-metastatic clear cell renal cell carcinoma.
Article in Journal of cancer research and clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Effects of Ciprofol and Propofol General Anesthesia on Postoperative Recovery Quality in Patients Undergoing Ureteroscopy: A Randomized, Controlled, Double-Blind Clinical Trial.Drug design, development and therapy · 2025Trial
- Quality of Recovery After General Anesthesia with Remimazolam in Patients' Undergoing Urologic Surgery: A Randomized Controlled Trial Comparing Remimazolam with Propofol.Drug design, development and therapy · 2022Trial
- CDK4/6 inhibitor combined with endocrine therapy: a real-world evaluation of efficacy and safety in HR+/HER2- advanced breast cancer.World journal of surgical oncology · 2026Article
- Competing risk of death in patients with low, intermediate and high risk of recurrence after radical surgery for clear cell renal cell carcinoma.BJUI compass · 2025Article
- Adolescent Obesity and Charlson Comorbidity Index in Young Adults.Journal of clinical medicine · 2025Article
- Charlson syndrome index predicted survival in pancreatic cancer patients received immunotherapy.Frontiers in immunology · 2025Article
- Longitudinal Trends of Comorbidities and Survival Among Kidney Cancer Patients in Asian Population.Cancer medicine · 2024Article
- Percutaneous Microwave Ablation versus Cryoablation for Small Renal Masses (≤4 cm): 12-Year Experience at a Single Center.Journal of vascular and interventional radiology : JVIR · 2024Article
- Nuclear protein NOP2 serves as a poor-prognosis predictor of LUAD and aggravates the malignancy of lung adenocarcinoma cells.Functional & integrative genomics · 2024Article
- Comprehensive analysis of ETS1 expression and its prognostic value in clear cell renal cell carcinoma.American journal of translational research · 2024Article
- Association of nutritional status and comorbidity with long-term survival among community-dwelling older males.BMC geriatrics · 2023Article
- The mitochondrial fusion-associated protein MFN2 can be used as a novel prognostic molecule for clear cell renal cell carcinoma.BMC cancer · 2023Article
- Review
- The impact of age and comorbidity on localized pancreatic cancer outcomes: A US retrospective cohort analysis with implications for surgical centralization.Surgery open science · 2023Article
- A Novel Predictive Model of Pathological Lymph Node Metastasis Constructed with Preoperative Independent Predictors in Patients with Renal Cell Carcinoma.Journal of clinical medicine · 2023Article
- The Prognostic Value of the Age-Adjusted Charlson Comorbidity Index Among the Elderly with Breast Cancer.Clinical interventions in aging · 2023Article
- The Four-Feature Prognostic Models for Cancer-Specific and Overall Survival after Surgery for Localized Clear Cell Renal Cancer: Is There a Place for Inflammatory Markers?Biomedicines · 2022Article
- Effect of the Age-Adjusted Charlson Comorbidity Index on All-Cause Mortality and Readmission in Older Surgical Patients: A National Multicenter, Prospective Cohort Study.Frontiers in medicine · 2022Article
- Nucleolar protein NOP2 could serve as a potential prognostic predictor for clear cell renal cell carcinoma.Bioengineered · 2021Article
- Image-guided percutaneous cryoablation of T1b renal cell carcinomas in patients with comorbidities.Japanese journal of radiology · 2021Article
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16 authors.
Funding
Abstract
purposeNo study has evaluated the prognostic impact of the age-adjusted Charlson comorbidity index (AACI) in those with renal cell carcinoma (RCC). This study aimed to evaluate the utility of the AACI for predicting long-term survival in patients with surgically treated non-metastatic clear cell RCC (ccRCC).
methodsData from 698 patients with non-metastatic ccRCC who underwent radical or partial nephrectomy as primary therapy from a multi-institutional Korean collaboration between 1988 and 2015 were retrospectively analyzed. Clinicopathological variables and survival outcomes of those with AACI scores ≤ 3 (n = 324), 4-5 (n = 292), and ≥ 6 (n = 82) were compared.
resultsPatients with a high AACI score were older and more likely to be female. They were also more likely to have diabetes or hypertension, a worse Eastern Cooperative Oncology Group performance status, and lower preoperative hemoglobin, albumin, serum calcium, and serum total cholesterol levels. Regarding pathologic features, a high AACI score was associated with advanced stage. Kaplan-Meier analyses revealed that AACI ≥ 6 was associated with shorter cancer-specific (log-rank test, P < 0.001) and overall survival (log-rank test, P < 0.001), but not with recurrence-free survival (log-rank test, P = 0.134). Multivariate Cox regression analyses identified an AACI score as an independent predictor of overall survival (hazard ratio, 6.870; 95% confidence interval, 2.049-23.031; P = 0.002). The AACI score was a better discriminator of overall survival than the Charlson comorbidity index score.
conclusionsAACI scores may enable more tailored, individualized management strategies for patients with surgically treated non-metastatic ccRCC.
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