Evidence map›Paper›PMID 31606759›Full record

ArticleJournal of neurology2020

Increased neural connectivity between the hypothalamus and cortical resting-state functional networks in chronic migraine.

Gianluca Coppola, Antonio Di Renzo, Barbara Petolicchio, Emanuele Tinelli, Cherubino Di Lorenzo, Mariano Serrao, Valentina Calistri, Stefano Tardioli, Gaia Cartocci, Vincenzo Parisi and 3 more

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Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Gianluca CoppolaDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy.
Antonio Di RenzoResearch Unit of Neurophysiology of Vision and Neurophthalmology, IRCCS-Fondazione Bietti, Via Livenza 3, 00198, Rome, Italy.
Barbara PetolicchioDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Emanuele TinelliDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Cherubino Di LorenzoDon Carlo Gnocchi Onlus Foundation, Milan, Italy.
Mariano SerraoDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy.
Valentina CalistriDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Stefano TardioliDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Gaia CartocciDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Vincenzo ParisiResearch Unit of Neurophysiology of Vision and Neurophthalmology, IRCCS-Fondazione Bietti, Via Livenza 3, 00198, Rome, Italy. vincenzo.parisi@fondazionebietti.it.
Francesca CaramiaDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Vittorio Di PieroDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Francesco PierelliDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe findings of resting-state functional MRI studies have suggested that abnormal functional integration between interconnected cortical networks characterises the brain of patients with migraine. The aim of this study was to investigate the functional connectivity between the hypothalamus, brainstem, considered as the migraine generator, and the following areas/networks that are reportedly involved in the pathophysiology of migraine: default mode network (DMN), executive control network, dorsal attention system, and primary and dorsoventral visual networks.

methodsTwenty patients with chronic migraine (CM) without medication overuse and 20 healthy controls (HCs) were prospectively recruited. All study participants underwent 3-T MRI scans using a 7.5-min resting-state protocol. Using a seed-based approach, we performed a ROI-to-ROI analysis selecting the hypothalamus as the seed.

resultsCompared to HCs, patients with CM showed significantly increased neural connectivity between the hypothalamus and brain areas belonging to the DMN and dorsal visual network. We did not detect any connectivity abnormalities between the hypothalamus and the brainstem. The correlation analysis showed that the severity of the migraine headache was positively correlated with the connectivity strength of the hypothalamus and negatively with the connectivity strength of the medial prefrontal cortex, which belongs to the DMN.

conclusionThese data provide evidence for hypothalamic involvement in large-scale reorganisation at the functional-network level in CM and in proportion with the perceived severity of the migraine pain.

Indexed as

ConnectomeAdultBrain MappingCerebral CortexFemaleHumansHypothalamusMagnetic Resonance ImagingMaleMiddle AgedMigraine DisordersNerve NetPrefrontal CortexProspective StudiesChronic migraineDefault mode networkDorsal visual networkfMRIResting state

Identifiers

PMID31606759

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.