Evidence map›Paper›PMID 31606476›Full record

ArticleBrain, behavior, and immunity2020

Allergic disease and low ASQ communication score in children.

Aishwarya P Yadama, Rachel S Kelly, Kathleen Lee-Sarwar, Hooman Mirzakhani, Su H Chu, Priyadarshini Kachroo, Augusto A Litonjua, Jessica Lasky-Su, Scott T Weiss

Open access · greenAbstract read
In one paragraph

Article in Brain, behavior, and immunity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Aishwarya P YadamaChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Rachel S KellyChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States. Electronic address: hprke@channing.harvard.edu.
Kathleen Lee-SarwarChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Hooman MirzakhaniChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Su H ChuChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Priyadarshini KachrooChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Augusto A LitonjuaDivision of Pediatric Pulmonary Medicine, University of Rochester Medical Center, Rochester, NY 14642, United States.
Jessica Lasky-SuChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Scott T WeissChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Harvard University · USUniversity of Rochester Medical Center · US

Funding

Systems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WEISS, SCOTT T · 2016 to 2020
$12.6M
Randomized Trial: Maternal Vitamin D Supplementation to Prevent Childhood AsthmaU01HL091528 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LITONJUA, AUGUSTO A, WEISS, SCOTT T · 2009 to 2013
$10.0M
RANDOMIZED CONTROLLED TRIAL: VDAART CONTINUATION STUDY - DCC - LEADR01HL091528 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LITONJUA, AUGUSTO A, WEISS, SCOTT T · 2014 to 2018
$9.1M
Integrative Metabolomics of Asthma SeverityR01HL123915 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2014 to 2023
$7.0M
Mechanistic insights into asthma pathogenesis through the integration of asthma genes, risk exposures, and metabolomicsR01HL141826 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LASKY-SU, JESSICA A · 2018 to 2021
$3.4M
Multi-Omic Endotyping of AsthmaK01HL146980 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KELLY, RACHEL SABINE · 2019 to 2023
$891k
NHLBI NIH HHS K01 HL146980NHLBI NIH HHS L30 HL129467NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL091528NHLBI NIH HHS R01 HL123915NHLBI NIH HHS R01 HL141826NHLBI NIH HHS U01 HL091528
6 · The paper itself

Abstract

Autism Spectrum Disorders (ASD) are complex and multifactorial. Previous investigations have revealed associations between allergic disease and ASD, which are characterized by impaired communication skills. In this study we observed an association between allergic disease and communication skills development as assessed by the Ages and Stages Questionnaire (ASQ) communication score, as a proxy for ASD, among children who participated in the Vitamin D Antenatal Asthma Reduction Trial (VDAART). In particular, we observed significant associations between both a diagnosis of eczema at age 3 years (OR = 1.87; confidence interval [CI]: 0.97-3.47; p = 0.054) and a diagnosis of food allergy at age 6 years (OR = 3.61; 95% CI: 1.18-9.85; p = 0.015) with ASQ communication score. Plasma metabolomics analyses suggest that dysregulated tryptophan metabolism may contribute to the pathogenesis of these co-morbidities.

Indexed as

CommunicationAsthmaAutism Spectrum DisorderChildChild, PreschoolEczemaFemaleFood HypersensitivityHumansMalePregnancySurveys and QuestionnairesTryptophanVitamin DTryptophanVitamin DAges and stages questionnaireAllergyASDAtopyAutismVDAART

Identifiers

PMID31606476
PMCPMC6906237
OpenAlexW2979929889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.