ArticleNeuroImage2020
Hippocampal GABA levels correlate with retrieval performance in an associative learning paradigm.
Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Effects of SSRI treatment on GABA and glutamate levels in an associative relearning paradigm.NeuroImage · 2021Trial
- Effects of bifrontal transcranial direct current stimulation on brain glutamate levels and resting state connectivity: multimodal MRI data for the cathodal stimulation site.European archives of psychiatry and clinical neuroscience · 2021Trial
- Human short-term memory learning based on dynamic glutamate levels and oscillatory activities: concurrent metabolic and electrophysiological studies using event-related functional-MRS and EEG modalities.Cognitive processing · 2026Article
- A polygenetic rat model of divergent aerobic capacity reveals a liver-brain interaction impacting Alzheimer's disease-like phenotypes.The Journal of physiology · 2026Article
- Neurotransmitter alterations in seasonal affective disorder.Scientific reports · 2026Article
- Hippocampal and prefrontal GABA and glutamate concentration contribute to component processes of working memory in aging.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- From theory to therapy: unlocking the potential of muscarinic receptor activation in schizophrenia with the dual M1/M4 muscarinic receptor agonist xanomeline and trospium chloride and insights from clinical trials.The international journal of neuropsychopharmacology · 2025Review
- Unveiling chiral amino acid alterations and glycine dysregulation in late-life depression through targeted metabolomics.Frontiers in psychiatry · 2025Article
- Unveiling Glutamate Dynamics: Cognitive Demands in Human Short-Term Memory Learning Across Frontal and Parieto-Occipital Cortex: A Functional MRS Study.Journal of biomedical physics & engineering · 2024Article
- MRS-assessed brain GABA modulation in response to task performance and learning.Behavioral and brain functions : BBF · 2024Review
- The potential of muscarinic MFrontiers in psychiatry · 2024Review
- Adolescent Δ-9-tetrahydrocannabinol exposure induces differential acute and long-term neuronal and molecular disturbances in dorsal vs. ventral hippocampal subregions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Article
- The glucocorticoid footprint on the memory engram.Current opinion in endocrine and metabolic research · 2022Article
- Multimodal mechanisms of human socially reinforced learning across neurodegenerative diseases.Brain : a journal of neurology · 2022Article
- Increased left dorsolateral prefrontal cortex density following escitalopram intake during relearning: a randomized, placebo-controlled trial in healthy humans.Therapeutic advances in psychopharmacology · 2022Article
- A role for GABA in the modulation of striatal and hippocampal systems under stress.Communications biology · 2021Article
- Hippocampal Interneurons are Required for Trace Eyeblink Conditioning in Mice.Neuroscience bulletin · 2021Article
- Epistemic Autonomy: Self-supervised Learning in the Mammalian Hippocampus.Trends in cognitive sciences · 2021Review
- Predicting learning and achievement using GABA and glutamate concentrations in human development.PLoS biology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural plasticity is a complex process dependent on neurochemical underpinnings. Next to the glutamatergic system which contributes to memory formation via long-term potentiation (LTP) and long-term depression (LTD), the main inhibitory neurotransmitter, GABA is crucially involved in neuroplastic processes. Hence, we investigated changes in glutamate and GABA levels in the brain in healthy participants performing an associative learning paradigm. Twenty healthy participants (10 female, 25 ± 5 years) underwent paired multi-voxel magnetic resonance spectroscopy imaging before and after completing 21 days of a facial associative learning paradigm in a longitudinal study design. Changes of GABA and glutamate were compared to retrieval success in the hippocampus, insula and thalamus. No changes in GABA and glutamate concentration were found after 21 days of associative learning. However, baseline hippocampal GABA levels were significantly correlated with initial retrieval success (p
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.