Evidence map›Paper›PMID 31606435›Full record

ArticleThe Lancet. Respiratory medicine2020

Lung function decline in former smokers and low-intensity current smokers: a secondary data analysis of the NHLBI Pooled Cohorts Study.

Elizabeth C Oelsner, Pallavi P Balte, Surya P Bhatt, Patricia A Cassano, David Couper, Aaron R Folsom, Neal D Freedman, David R Jacobs, Ravi Kalhan, Amanda R Mathew and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet. Respiratory medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 4 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 4 syntheses or guidelines pooled it, 172 citations in OpenAlex.

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  6. Reengagement for Long-Term Smoking-Cessation In Military Personnel, Retirees, Family Members (TRICARE): A Randomized Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 1 country.

Elizabeth C OelsnerColumbia University, New York, NY, USA. Electronic address: eco7@cumc.columbia.edu.
Pallavi P BalteColumbia University, New York, NY, USA.
Surya P BhattUniversity of Alabama at Birmingham, Birmingham, AL, USA.
Patricia A CassanoCornell University, Ithaca, NY, USA.
David CouperUniversity of North Carolina, Chapel Hill, NC, USA.
Aaron R FolsomUniversity of Minnesota, Minneapolis, MN, USA.
Neal D FreedmanDivision of Cancer Epidemiology & Genetics, National Cancer Institute, Bethesda, MD, USA.
David R JacobsUniversity of Minnesota, Minneapolis, MN, USA.
Ravi KalhanNorthwestern University, Chicago, IL, USA.
Amanda R MathewRush University Medical Center, Chicago, IL, USA.
Richard A KronmalUniversity of Washington, Seattle, WA, USA.
Laura R LoehrUniversity of North Carolina, Chapel Hill, NC, USA.
Stephanie J LondonNational Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.
Anne B NewmanUniversity of Pittsburgh, Pittsburgh, PA, USA.
George T O'ConnorBoston University, Boston, MA, USA.
Joseph E SchwartzColumbia University, New York, NY, USA.
Lewis J SmithNorthwestern University, Chicago, IL, USA.
Wendy B WhiteTougaloo College, Tougaloo, MS, USA.
Sachin YendeUniversity of Pittsburgh, Pittsburgh, PA, USA.
Columbia University · USNorthwestern University · USUniversity of Minnesota · USUniversity of North Carolina at Chapel Hill · USUniversity of Pittsburgh · USCornell University · USDivision of Cancer Epidemiology and GeneticsNational Institutes of Health · USRush University Medical Center · USTougaloo College · USUniversity of Alabama at Birmingham · USUniversity of Washington · US

Funding

Upper Gastrointestinal Cancer StudiesZIACP000185 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ABNET, CHRISTIAN · 2009 to 2025
$25.6M
Pulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8M
Transitions from Impaired Respiratory Health to Lung DiseaseR01HL122477 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RAVI KALHAN · 2014 to 2026
$17.3M
Pulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Chronic obstructive pulmonary disease in non-smokersR01HL130506 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HERBSTMAN, JULIE BETH, SMITH, BENJAMIN M. · 2016 to 2025
$6.3M
CHS Events Follow-up StudyU01HL080295 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2005 to 2008
$4.6M
Peripheral Nerve Function Decline in an Aged CohortR01AG028050 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STROTMEYER, ELSA S. · 2007 to 2015
$3.5M
End of Life in the Very OldR01NR012459 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ALBERT, STEVEN M, LUNNEY, JUNE R · 2011 to 2015
$2.7M
Cigarette Smoke and Susceptibility to Influenza InfectionR01HL095163 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JASPERS, ILONA, NOAH, TERRY L · 2009 to 2013
$2.0M
Role of EIIIA fibronectin in pulmonary fibrosisR01HL085083 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WHITE, ERIC S · 2007 to 2011
$1.9M
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6 · The paper itself

Abstract

backgroundFormer smokers now outnumber current smokers in many developed countries, and current smokers are smoking fewer cigarettes per day. Some data suggest that lung function decline normalises with smoking cessation; however, mechanistic studies suggest that lung function decline could continue. We hypothesised that former smokers and low-intensity current smokers have accelerated lung function decline compared with never-smokers, including among those without prevalent lung disease.

methodsWe used data on six US population-based cohorts included in the NHLBI Pooled Cohort Study. We restricted the sample to participants with valid spirometry at two or more exams. Two cohorts recruited younger adults (≥17 years), two recruited middle-aged and older adults (≥45 years), and two recruited only elderly adults (≥65 years) with examinations done between 1983 and 2014. FEV

findings25 352 participants (ages 17-93 years) completed 70 228 valid spirometry exams. Over a median follow-up of 7 years (IQR 3-20), FEV

interpretationFormer smokers and low-intensity current smokers have accelerated lung function decline compared with never-smokers. These results suggest that all levels of smoking exposure are likely to be associated with lasting and progressive lung damage.

fundingNational Institutes of Health, National Heart Lung and Blood Institute, and US Environmental Protection Agency.

Indexed as

AdultAgedCase-Control StudiesEx-SmokersFemaleFollow-Up StudiesHumansLungMaleMiddle AgedNational Heart, Lung, and Blood Institute (U.S.)Non-SmokersRespiratory Physiological PhenomenaSmokersSmokingSpirometry

Identifiers

PMID31606435
PMCPMC7261004
OpenAlexW2980306497

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.