Evidence map›Paper›PMID 31606366›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2019

Sex/gender differences in cognitive trajectories vary as a function of race/ethnicity.

Justina F Avila, Jet M J Vonk, Steven P Verney, Katie Witkiewitz, Miguel Arce Rentería, Nicole Schupf, Richard Mayeux, Jennifer J Manly

Open access · greenAbstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Sex differences in vulnerability to tau pathology: Impact on cognitive decline.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  7. Article
  8. Radical Imagination: An Afrofuturism and Creative Aging Program for Black Women's Brain Health and Wellness.International journal of environmental research and public health · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Allostatic load and cognitive recall among young adults: Racial, ethnic, and sex-specific variations.Journal of the International Neuropsychological Society : JINS · 2024
    Article
  15. Article
  16. Observational
  17. Sex and gender differences in cognitive resilience to aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Justina F AvilaDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Jet M J VonkTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Steven P VerneyDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Katie WitkiewitzDepartment of Psychology, University of New Mexico, Albuquerque, NM, USA.
Miguel Arce RenteríaTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Nicole SchupfTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Richard MayeuxTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Jennifer J ManlyTaub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address: jjm71@columbia.edu.
Columbia University · USUniversity of New Mexico · US

Funding

VASCULAR FACTORS AND MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASEP01AG007232 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MAYEUX, RICHARD P · 1989 to 2008
$21.7M
Epidemiology of Biomarkers of Risk and Progression in LOADR01AG037212 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P, SCHUPF, NICOLE · 2010 to 2015
$10.1M
Genetic Epidemiology of Cerebrovascular Factors in Alzheimer's DiseaseRF1AG054023 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAYEUX, RICHARD P · 2016 to 2018
$8.9M
Transdisciplinary Research, Equity and Engagement Center for Advancing Behavioral HealthU54MD004811 · NIMHD · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI CACARI STONE, LISA MARIE · 2017 to 2022
$8.7M
White matter hyperintensities in Aging and DementiaR01AG034189 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M · 2010 to 2014
$2.0M
White Matter Hyperintentisities in Aging and DementiaR56AG034189 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BRICKMAN, ADAM M · 2016 to 2016
$793k
Psychosocial Protective Factors in Cognitive and Brain AgingR00AG047963 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZAHODNE, LAURA B · 2016 to 2018
$746k
Psychosocial protective factors in cognitive and brain agingK99AG047963 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZAHODNE, LAURA B · 2014 to 2015
$264k
NIA NIH HHS K99 AG047963NIA NIH HHS P01 AG007232NIA NIH HHS R00 AG047963NIA NIH HHS R01 AG034189NIA NIH HHS R01 AG037212NIA NIH HHS R56 AG034189NIA NIH HHS RF1 AG054023NIMHD NIH HHS U54 MD004811
6 · The paper itself

Abstract

introductionThe present study sought to determine whether cognitive trajectories differ between men and women across and within racial/ethnic groups.

methodsParticipants were 5258 non-Hispanic White (NHW), Black, and Hispanic men and women in the Washington/Hamilton Heights-Inwood Columbia Aging Project who were administered neuropsychological tests of memory, language, and visuospatial abilities at 18- to 24-month intervals for up to 25 years. Multiple-group latent growth curve modeling examined trajectories across sex/gender by race/ethnicity.

resultsAfter adjusting for age and education, the largest baseline differences were between NHW men and Hispanic women on visuospatial and language, and between NHW women and Black men on memory. Memory and visuospatial decline was steeper for Black women compared with Hispanic men and NHW women, respectively. DISCUSSION: This study takes an important first step in understanding interactions between race/ethnicity and sex/gender on cognitive trajectories by demonstrating variability in sex/gender differences across race/ethnicity.

Indexed as

CognitionAgedAgingBlack or African AmericanCognitive AgingCognitive DysfunctionDementiaEthnicityFemaleHispanic or LatinoHumansLanguageLongitudinal StudiesMaleMemoryNeuropsychological TestsCognitive agingCognitive trajectoriesDementiaRacial/ethnic differencesSex/gender differences

Identifiers

PMID31606366
PMCPMC6925640
OpenAlexW2979574592

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.