ArticleBehavioural brain research2020
Pre-training inactivation of basolateral amygdala and mediodorsal thalamus, but not orbitofrontal cortex or prelimbic cortex, impairs devaluation in a multiple-response/multiple-reinforcer cued operant task.
Article in Behavioural brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Distinct mediodorsal-prefrontal loops differentially encode reward-predictive cues.bioRxiv : the preprint server for biology · 2026Article
- Mediodorsal Thalamic Input to Striatum Contributes to Early Action Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neither Amphetamine nor Sub-Anesthetic Ketamine Treatment during Adolescence Impairs Devaluation in Rats Tested during Adulthood.Journal of integrative neuroscience · 2024Article
- Prelimbic cortex neural encoding dynamically tracks expected outcome value.Physiology & behavior · 2022Article
- Necessity and recruitment of cue-specific neuronal ensembles within the basolateral amygdala during appetitive reversal learning.Neurobiology of learning and memory · 2022Article
- Extended operant training increases infralimbic and prelimbic cortex Fos regardless of fear conditioning experience.Behavioural brain research · 2021Article
- The orbitofrontal cortex in temporal cognition.Behavioral neuroscience · 2021Review
- Effects of Limited and Extended Pavlovian Training on Devaluation Sensitivity of Sign- and Goal-Tracking Rats.Frontiers in behavioral neuroscience · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Reinforcer devaluation is a task often used to model flexible goal-directed behavior. Here, we inactivated basolateral amygdala (BLA), orbitofrontal cortex (OFC), mediodorsal thalamus (MD) (Exp. 1) and prelimbic cortex (PL) (Exp. 3) in rats during multiple-response/multiple-reinforcer operant training with levers available to earn reinforcers during cued trials. After two training days with each lever-food relationship, a reinforcer was devalued through selective satiety and devaluation was assessed in a choice test with the brain areas non-inactivated. The control and OFC and PL inactivation groups exhibited a devaluation effect, but the BLA or MD groups did not. Since the OFC is proposed to be required in devaluation tasks when a discrete cue signals an outcome and PL is proposed to be required when responses based on lever spatial-location guide behavior, we ran new rats through a cue-switching experiment (Exp. 2) to determine the strategy rats use to complete our task (attending to the discrete light cue or spatial lever location). Both groups (cue switched and cue normal) showed a devaluation effect based on the lever spatial location, suggesting that rats rely on the spatial lever location to guide behavior. Future studies will determine whether OFC and PL can compensate for each other to show intact devaluation when the functioning of one of them is impaired.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.