ArticleChembiochem : a European journal of chemical biology2020
Modeling Alcohol Dehydrogenase Catalysis in Deep Eutectic Solvent/Water Mixtures.
Article in Chembiochem : a European journal of chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- From Hydrogen Bonding to Hydrophobic Control: The Shifting Solvation Mechanism of Ibuprofen in Deep Eutectic Solvents.The journal of physical chemistry. B · 2026Article
- Scaling Up Is Not the Same but Bigger: Overcoming (Some) Limitations in Enzymatic Decarboxylations in Rotating Bed Reactors in Deep Eutectic Solvents.Organic process research & development · 2026Article
- Molar-Scale Phenolic Acid Decarboxylation Using Thermostable Biocatalysts and Enzyme-Compatible Deep Eutectic Solvents.ChemSusChem · 2025Article
- A Computational Perspective to Intermolecular Interactions and the Role of the Solvent on Regulating Protein Properties.Chemical reviews · 2025Review
- Redox Biocatalysis in Lidocaine-Based Hydrophobic Deep Eutectic Solvents: Non-Conventional Media Outperform Aqueous Conditions.ChemSusChem · 2025Article
- Optimized Spatial Configuration of Heterogeneous Biocatalysts Maximizes Cell-Free Biosynthesis of ω-Hydroxy and ω-Amino Acids.ACS sustainable chemistry & engineering · 2024Article
- Integrated preservation of water activity as key to intensified chemoenzymatic synthesis of bio-based styrene derivatives.Communications chemistry · 2024Article
- How Can Deep Eutectic Systems Promote Greener Processes in Medicinal Chemistry and Drug Discovery?Pharmaceuticals (Basel, Switzerland) · 2024Review
- Investigating Biomolecules in Deep Eutectic Solvents with Molecular Dynamics Simulations: Current State, Challenges and Future Perspectives.Molecules (Basel, Switzerland) · 2024Review
- Rational design of deep eutectic solvents for the stabilization of dehydrogenases: an artificial neural network prediction approach.Frontiers in chemistry · 2024Article
- Laccase-catalyzed lignin depolymerization in deep eutectic solvents: challenges and prospects.Bioresources and bioprocessing · 2023Review
- Computer Simulations of Deep Eutectic Solvents: Challenges, Solutions, and Perspectives.International journal of molecular sciences · 2022Review
- Modeling Alcohol Dehydrogenase Catalysis in Deep Eutectic Solvent/Water Mixtures.Chembiochem : a European journal of chemical biology · 2020Article
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5 authors.
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Abstract
The use of oxidoreductases (EC1) in non-conventional reaction media has been increasingly explored. In particular, deep eutectic solvents (DESs) have emerged as a novel class of solvents. Herein, an in-depth study of bioreduction with an alcohol dehydrogenase (ADH) in the DES glyceline is presented. The activity and stability of ADH in mixtures of glyceline/water with varying water contents were measured. Furthermore, the thermodynamic water activity and viscosity of mixtures of glyceline/water have been determined. For a better understanding of the observations, molecular dynamics simulations were performed to quantify the molecular flexibility, hydration layer, and intraprotein hydrogen bonds of ADH. The behavior of the enzyme in DESs follows the classic dependence of water activity (a
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