Evidence map›Paper›PMID 31605569›Full record

ArticleFEBS open bio2019

Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.

Qingqing Li, Shasha Geng, Huixiao Yuan, Yang Li, Shuxian Zhang, Lin Pu, Jianli Ge, Xianping Niu, Yandong Li, Hua Jiang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 25 citations in OpenAlex.

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  18. Emerging Roles of Exosomal Circular RNAs in Cancer.Frontiers in cell and developmental biology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Qingqing LiShanghai East Hospital, Nanjing Medical University, Shanghai, China.ORCID 0000-0002-1154-3719
Shasha GengDepartment of Geriatrics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Huixiao YuanDepartment of Geriatrics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Yang LiDepartment of Geriatrics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Shuxian ZhangShanghai East Hospital, Nanjing Medical University, Shanghai, China.
Lin PuDepartment of Geriatrics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Jianli GeDepartment of Geriatrics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Xianping NiuDepartment of Geriatrics, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Yandong LiResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Hua JiangShanghai East Hospital, Nanjing Medical University, Shanghai, China.
Shanghai East Hospital · CNShanghai Medical College of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor-derived extracellular vesicles (EVs) and their contents are involved in the development of human malignancies. Circular RNAs (circRNAs), enriched in EVs, can regulate diverse cellular processes by acting as microRNA (miRNA) sponges or through other mechanisms. In the present study, we explored the potential roles of circRNAs in EVs in the development of pancreatic ductal adenocarcinoma (PDAC). First, plasma was obtained from patients with PDAC (n = 8) and healthy volunteers (n = 8), and EVs were isolated by the ultracentrifugation method. Nanoparticle tracking analysis and transmission electron microscopy confirmed the size and form of the isolated EVs. The circRNA expression profiles of EVs were investigated by high-throughput whole transcriptome sequencing. We then further validated the accuracy of the circRNA sequencing data by quantitative real-time PCR analysis using plasma samples and PC cell lines, and subsequently performed bioinformatics analysis to reveal the potential functional roles of the differentially expressed circRNAs and to construct a circRNA-miRNA interaction network to predict the target miRNAs of these circRNAs. Our work provides novel targets for further studies concerning the pathogenesis of PDAC.

Indexed as

AdenocarcinomaAdultCarcinoma, Pancreatic DuctalCell Line, TumorComputational BiologyExtracellular VesiclesFemaleGene Expression ProfilingHumansMaleMicroRNAsPancreatic NeoplasmsReal-Time Polymerase Chain ReactionRNA, CircularTranscriptomeMicroRNAsRNA, Circularcircular RNAextracellular vesiclesmicroRNApancreatic ductal adenocarcinoma

Identifiers

PMID31605569
PMCPMC6886294
OpenAlexW2980169489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.