Evidence map›Paper›PMID 31605461›Full record

ArticlePhysiological reports2019

Urinary angiotensinogen antedates the development of stage 3 CKD in patients with type 1 diabetes mellitus.

Sheeba Ba Aqeel, Minghao Ye, Jan Wysocki, Alejandro Sanchez, Ahmed Khattab, Enrique Lores, Alfred Rademaker, Xiaoyu Gao, Ionut Bebu, Robert G Nelson and 3 more

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Precision Nephrology in Patients with Diabetes and Chronic Kidney Disease.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Sheeba Ba AqeelNorthwestern University Feinberg School of Medicine, Chicago, Illinois.
Minghao YeNorthwestern University Feinberg School of Medicine, Chicago, Illinois.
Jan WysockiNorthwestern University Feinberg School of Medicine, Chicago, Illinois.
Alejandro SanchezNorthwestern University Feinberg School of Medicine, Chicago, Illinois.
Ahmed KhattabNorthwestern University Feinberg School of Medicine, Chicago, Illinois.
Enrique LoresNorthwestern University Feinberg School of Medicine, Chicago, Illinois.
Alfred RademakerNorthwestern University Feinberg School of Medicine, Chicago, Illinois.
Xiaoyu GaoGeorge Washington University, Rockville, Maryland.
Ionut BebuGeorge Washington University, Rockville, Maryland.
Robert G NelsonNational Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, Arizona.
Mark MolitchNorthwestern University Feinberg School of Medicine, Chicago, Illinois.
Daniel BatlleNorthwestern University Feinberg School of Medicine, Chicago, Illinois.ORCID 0000-0002-5878-9046
Diabetes Control, Complications Trial (DCCT)/Epidemiology of Diabetes Interventions, Complications (EDIC) Study
Northwestern University · USGeorge Washington University · USNational Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Clinical Research Center (Collaborative U01)U01DK094157 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2011 to 2026
$97.6M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Epidemiology of Diabetes Interventions and Complications Data Coordinating CenterU01DK094176 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BEBU, IONUT, BRAFFETT, BARBARA HALINA · 2012 to 2022
$30.8M
Nocturnal Hypertension and Prevention of Microalbuminuria in Type I DiabeticsU01DK071733 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MOLITCH, MARK ELLIS · 2006 to 2010
$1.7M
Urinary Renin Angiotensin System in DiabetesR01DK104785 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BATLLE, DANIEL · 2015 to 2017
$939k
NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK104785NIDDK NIH HHS R01DK104785NIDDK NIH HHS U01 DK071733NIDDK NIH HHS U01-DK071733-01A1NIDDK NIH HHS U01 DK094157NIDDK NIH HHS U01 DK094176
6 · The paper itself

Abstract

We examined if urinary angiotensinogen (uAOG), a marker of intrarenal renin-angiotensin system activity, antedates stage 3 chronic kidney disease (CKD) using samples from participants in the Diabetes Control and Complications Trial (DCCT) and later in the Epidemiology of Diabetes Intervention and Complications (EDIC) trial. In a nested case-control design, cases were matched at the outcome visit (eGFR less than 60, 21-59 mL/min per 1.73 m

Indexed as

AdolescentAdultAngiotensinogenBiomarkersCase-Control StudiesDiabetes Mellitus, Type 1Diabetic NephropathiesFemaleHumansMaleMiddle AgedRenal Insufficiency, ChronicYoung AdultAGT protein, humanAngiotensinogenBiomarkersbiomarkerschronic kidney diseasediabeteshypertensionrenin angiotensin systemurinary angiotensinogen

Identifiers

PMID31605461
PMCPMC6788980
OpenAlexW2979379227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.