Evidence map›Paper›PMID 31605414›Full record

ArticleJournal of clinical laboratory analysis2020

Association of GWAS-supported noncoding area loci rs404860, rs3117098, and rs7775228 with asthma in Chinese Zhuang population.

Si-Qiao Liang, Jing-Min Deng, Xuan Wei, Zhang-Rong Chen, Mei-Ling Yang, Hua-Jiao Qin, Jian-Quan Zhang, Zhi-Yi He

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In one paragraph

Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Si-Qiao LiangDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jing-Min DengDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China.ORCID https://orcid.org/0000-0003-0189-5371
Xuan WeiDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zhang-Rong ChenDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Mei-Ling YangDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Hua-Jiao QinDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jian-Quan ZhangDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zhi-Yi HeDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Funding

Natural Science Foundation of Guangxi Province 2017GXNSFAA198104Young and Middle Teachers Basic Capacity Improvement Project of Guangxi higher education institutions 2017KY0101Young and Middle Teachers Basic Capacity Improvement Project of Guangxi higher education institutions 2018KY0137
6 · The paper itself

Abstract

backgroundAsthma is a complicated and polygenic inheritance disease, and its prevalence increases worldwide. Recent genome-wide association studies (GWASs) identified a significant association of single nucleotide polymorphism with asthma in the Japanese population. This study aimed to examine the association of GWAS-supported noncoding area loci, namely rs404860, rs3117098, and rs7775228, with asthma in Chinese Zhuang population.

methodsA case-control study involving 223 individuals, comprising 123 patients with asthma and 100 healthy controls, was conducted. Genotypes were determined by polymerase chain reaction (PCR)/ligase detection reaction assay. The association between gene polymorphisms and asthma risk was calculated by logistic regression analysis using different genetic models through comparisons of alleles (A vs a), homozygote genotypes (AA vs aa), heterozygote genotypes (Aa vs aa), dominant models (AA+Aa vs aa), and recessive models (AA vs. Aa+aa).

resultsThe distribution of the genotype frequency of rs3117098 was statistically different between the case and control groups. For rs3117098, significant associations were observed through comparisons of alleles (OR: 1.832, 95% CI: 1.048-3.204, P = .034) and dominant models (OR: 2.065, 95% CI: 1.001-4.260, P = .050). The statistical analysis showed no significant difference for loci rs404860 and rs7775228 between patients with asthma and controls.

conclusionrs3117098 may be the risk factor for asthma in Chinese Zhuang population.

Indexed as

Polymorphism, Single NucleotideAdultAllelesAsian PeopleAsthmaButyrophilinsCase-Control StudiesChinaFemaleGene FrequencyGenetic Predisposition to DiseaseGenome-Wide Association StudyHLA-DQ AntigensHumansMaleReceptor, Notch4BTNL2 protein, humanButyrophilinsHLA-DQA2 antigenHLA-DQ AntigensNOTCH4 protein, humanReceptor, Notch4asthmaGWAS-supportednoncoding area lociZhuang population

Identifiers

PMID31605414
PMCPMC7031573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.