ArticleJournal of child psychology and psychiatry, and allied disciplines2020
Evaluating chronic emotional dysregulation and irritability in relation to ADHD and depression genetic risk in children with ADHD.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 6 of them syntheses that pooled it.
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Who cites it
75 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- A meta-analytic review of the impact of ADHD medications on anxiety and depression in children and adolescents.European child & adolescent psychiatry · 2023Pooled it
- Trans-ancestry meta-analysis of genome wide association studies of inhibitory control.Molecular psychiatry · 2023Pooled it
- Systematic Review: How the Attention-Deficit/Hyperactivity Disorder Polygenic Risk Score Adds to Our Understanding of ADHD and Associated Traits.Journal of the American Academy of Child and Adolescent Psychiatry · 2021Pooled it
- Can polygenic risk scores help identify pediatric bipolar spectrum and related disorders?: A systematic review.Psychiatry research · 2021Pooled it
- Polygenic Scores for ADHD: A Meta-Analysis.Research on child and adolescent psychopathology · 2021Pooled it
- Unpacking early risks for peer victimization: A network analysis of early temperament and polygenic risk scores.JCPP advances · 2026Article
- Emotional Profiles in Adolescents With ADHD: A Person-Centered Analysis of Emotion Regulation, Resilience, and Internalizing Symptoms.Alpha psychiatry · 2026Article
- Frustrative non-reward: A cross-species probe to study brain mechanisms of irritability.Translational psychiatry · 2026Review
- Irritability in preschool children with attention-deficit/hyperactivity disorder: Analysis of family environmental factors.JCPP advances · 2026Article
- Emotion Dysregulation in Children with ADHD: Irritability is Associated with EEG-Measured Frontal Alpha Asymmetry in Response to Emotional Stimuli.Research on child and adolescent psychopathology · 2026Article
- Article
- Mapping phenotypic and genetic relationships among irritability, depression and ADHD in adolescence using network analysis.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- The Evolving ADHD Phenotype in the Externalizing Context.The American journal of psychiatry · 2026Review
- Reactivity and regulation of negative and positive emotions in child- and adolescent diagnostic and trait-level ADHD: a cross-sectional study.BMC psychiatry · 2025Article
- Distinct neuroimaging subtypes of ADHD among adolescents based on semi-supervised learning.Translational psychiatry · 2025Article
- Irritability in children with RASopathies, insights into emotional dysregulation and social impairment.European child & adolescent psychiatry · 2025Article
- Factors Associated With Medication Adherence Among Patients With Attention-Deficit/Hyperactivity Disorder (ADHD).Journal of attention disorders · 2025Observational
- Differences in Resting-State Functional Connectivity of Temperament-Based Profiles Among Youths With Attention-Deficit/Hyperactivity Disorder in the Adolescent Brain Cognitive Development Study.Clinical psychological science : a journal of the Association for Psychological Science · 2025Article
- The association between temperament and polygenic score for psychopathology from infancy to middle childhood.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundA central nosological problem concerns the etiological relationship of emotional dysregulation with ADHD. Molecular genetic risk scores provide a novel method for informing this question.
methodsParticipants were 514 community-recruited children of Northern European descent age 7-11 defined as ADHD or non-ADHD by detailed research evaluation. Parents-rated ADHD on standardized ratings and child temperament on the Temperament in Middle Childhood Questionnaire (TMCQ) and reported on ADHD and comorbid disorders by semi-structured clinical interview. Categorical and dimensional variables were created for ADHD, emotional dysregulation (implicating disruption of regulation of both anger-irritability and of positive valence surgency-sensation seeking), and irritability alone (anger dysregulation). Genome-wide polygenic risk scores (PRS) were computed for ADHD and depression genetic liability. Structural equation models and computationally derived emotion profiles guided analysis.
resultsThe ADHD PRS was associated in variable-centered analyses with irritability (β = .179, 95% CI = 0.087-0.280; ΔR
conclusionsIrritability-anger and surgency-sensation seeking, as forms of negative and positively valenced dysregulated affect in ADHD populations, both relate principally to ADHD genetic risk and not mood-related genetic risk.
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