Evidence map›Paper›PMID 31605356›Full record

ArticleAnnals of nuclear medicine2020

Kentaro Fujiwara, Atsushi B Tsuji, Hitomi Sudo, Aya Sugyo, Hiroki Akiba, Hiroko Iwanari, Osamu Kusano-Arai, Kouhei Tsumoto, Toshimitsu Momose, Takao Hamakubo and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Annals of nuclear medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Cadherin 17 and digestive cancers: from diagnostic to therapeutic opportunities.Journal of experimental & clinical cancer research : CR · 2026
    Review
  2. Article
  3. Development and Characterization of the [Molecular pharmaceutics · 2025
    Article
  4. Article
  5. Article
  6. Cadherin-17 as a target for the immunoPET of adenocarcinoma.European journal of nuclear medicine and molecular imaging · 2024
    Article
  7. Article
  8. Review
  9. Article
  10. Antibody-Targeted Imaging of Gastric Cancer.Molecules (Basel, Switzerland) · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Kentaro FujiwaraDepartment of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology (QST-NIRS), 4-9-1 Anagawa, Inage, 263-8555, Chiba, Japan.
Atsushi B TsujiDepartment of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology (QST-NIRS), 4-9-1 Anagawa, Inage, 263-8555, Chiba, Japan. tsuji.atsushi@qst.go.jp.ORCID http://orcid.org/0000-0003-2726-288X
Hitomi SudoDepartment of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology (QST-NIRS), 4-9-1 Anagawa, Inage, 263-8555, Chiba, Japan.
Aya SugyoDepartment of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology (QST-NIRS), 4-9-1 Anagawa, Inage, 263-8555, Chiba, Japan.
Hiroki AkibaLaboratory of Pharmacokinetic Optimization, Center for Drug Design Research, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Hiroko IwanariDepartment of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Osamu Kusano-AraiDepartment of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Kouhei TsumotoDepartment of Bioengineering, School of Engineering, The University of Tokyo, Tokyo, Japan.
Toshimitsu MomoseDepartment of Radiology, Faculty of Medicine, International University of Health and Welfare, Chiba, Japan.
Takao HamakuboDepartment of Quantitative Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Tatsuya HigashiDepartment of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology (QST-NIRS), 4-9-1 Anagawa, Inage, 263-8555, Chiba, Japan.
National Institutes for Quantum Science and Technology · JPThe University of Tokyo · JPInternational University of Health and Welfare · JPNational Institute of Biomedical Innovation, Health and Nutrition · JP

Funding

Japan Agency for Medical Research and Development JP15cm0106152Japan Agency for Medical Research and Development JP17cm0106421Japan Agency for Medical Research and Development JP18gm0710003KAKENHI 17K10497KAKENHI 18H02774KAKENHI 18K07778KAKENHI JP16K19809KAKENHI JP18K15335
6 · The paper itself

Abstract

objectiveCadherin-17 (CDH17) is a transmembrane protein that mediates cell-cell adhesion and is frequently expressed in adenocarcinomas, including gastric cancer. CDH17 may be an effective diagnostic marker for the staging of gastric cancer. Here, we developed an

methodsThe cross-reactivity and affinity of our anti-CDH17 Mab D2101 was evaluated by surface plasmon resonance analysis and cell enzyme-linked immunosorbent assay, respectively. Biodistribution and SPECT/CT studies of

resultsSurface plasmon resonance analysis revealed that D2101 specifically recognizes human CDH17, but not murine CDH17. The affinity of D2101 slightly decreased as a result of the radiolabeling procedures. The biodistribution study revealed high uptake of

conclusionOur

Indexed as

AnimalsCadherinsCell Line, TumorCell Transformation, NeoplasticGene Expression Regulation, NeoplasticHumansImmunoconjugatesIndium RadioisotopesIsotope LabelingLymphatic MetastasisMiceNeoplasm StagingSingle Photon Emission Computed Tomography Computed TomographyStomach NeoplasmsTissue DistributionCadherinsCDH17 protein, humanImmunoconjugatesIndium-111Indium RadioisotopesCadherin-17Gastric cancerLymph-node metastasisRadiolabeled antibodySPECT

Identifiers

PMID31605356
PMCPMC6970965
OpenAlexW2979813404

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.